Research Associate II Medicinal Chemistry, Automation

Embedded within theBroad Institute theCenter for the Development of Therapeutics(CDoT) is a highly collaborative organization of professional drug discovery scientists. Our mission is to translate cutting edge biological insights originating from the Broad community into impactful drug discovery projects. We partner with faculty from MIT Harvard and the Harvard teaching hospitals together with industry partners in pharmaceutical biotechnology and venture capital firms to validate druggable targets and identify leads. We combine our deep expertise in drug discovery with the knowledge and unique capabilities of the Broad Institute to address a wide range of disease areas (including oncology cardiovascular psychiatry infectious and rare diseases). We use systematic approaches in genomics biology chemistry and machine learning coupled with the Broads culture of creativity risk taking and open sharing to successfully advance science and develop new treatments for patients. We also create new technologies and work to combine the unique capabilities of the Broad Institute to enable new therapeutic approaches that will broadly benefit the scientific community.

Position Summary

We are currently seeking a highly motivated and passionate bench-based synthetic organic chemist to support an early drug discovery project by synthesizing chemical small molecules. Additionally this candidate will support our compound management and automation teams by maintaining and distributing the Broads vast collection of small molecule compounds. The successful candidate will have experience with modern synthetic and purification techniques and in the characterization of small molecules. Experience in medicinal chemistry is a plus. We will provide medicinal chemistry training to support the candidate if needed.

Key Responsibilities

Synthesize isolate and purify novel small molecules to advance ongoing projects

Accurately document all laboratory work in electronic notebook in a timely manner

With the supervisor analyze and troubleshoot chemical reactions

Effectively present results to internal teams

Working in partnership with team members and collaborators to deliver on project goals and milestones.

Work closely with CDoT Compound Management and Automation teams to fulfill requests receive and distribute small molecule compounds including operating automated robotic systems and acoustic liquid handlers.

Required qualifications

BS/BA in Chemistry or a closely related field with 2 years postgraduate organic chemistry / medicinal chemistry research experience (industry experience preferred) or an MS in chemistry with 0 years postgraduate organic chemistry / medicinal chemistry research experience.

Experience with multi-step chemical synthesis

Experience with modern normal phase and reverse phase chromatography and HPLC purification techniques

Experience with obtaining interpreting and analyzing LCMS and NMR spectra to support compound characterization

A proven record of successful communication of scientific results and positive interactions in a team setting

The successful candidate will be a results-focused team-oriented scientist able to excel in a fast-track environment. They must be accountable self-motivated detail-oriented and exhibit problem solving addition the successful candidate will be a clear and effective communicator demonstrating strong interpersonal skills to enable collaboration with team members.

WORKING CONDITIONS

Normal laboratory conditions

Normal office conditions

The Broad Institute will not offer visa sponsorship for this opportunity.

Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled