Mechanistic Chemist – Process Chemistry

Location: Macclesfield UK

Salary: Competitive Salary and Benefits!

Introduction to role:

Are you ready to turn deep mechanistic insight into scalable sustainable processes that speed life-changing medicines to patients In this role you will combine Physical Organic Chemistry with digital modelling and automation to transform lab discoveries into robust manufacturing routes that deliver quality reproducibility and efficiency.

In Chemical Development we believe that nothing is impossible and we are determined to push the boundaries of science to deliver medicines to our patients. We combine peoples technical knowledge and understanding with their talent and drive to design develop and optimise synthetic routes and processes that deliver the active pharmaceutical ingredients of our medicines in a sustainable commerciallyviableway. We believe in innovation and continuous improvement working closely with colleagues in academia and across industry to ensure that we apply thecutting-edgetechnologies and principles in the processes we develop.

About the role:

We have an exciting opportunityatSenior Scientistlevelto joinourchemistryprocessmodellingandautomationteamasaMechanisticChemist.

Asamechanistic-focusedprocess chemist working closely with analytical chemists engineersscientistsand thedata science organisation you willusePhysical OrganicChemistry(POC)principles tocontribute todrug-substance chemistry withinpharmaceuticaltechnology andDevelopment(PT&D).Supportingprojectstoensureprogressionthrough development and launch. You may leadactivitiescoachingother scientists.

Join us because you believe in doing all of this with transparency doing the right thing in all our operations and interactions.

Key Responsibilities:

• Designand optimisationof chemical processes suitable for scale-up with a focus onmechanisticprocessunderstandingand predictionusingin silicomodelling.Workingwithout direct supervision andwiththe ability totrain less experienced scientisttoinitiate direct and perform experimental work and implement strategies.

• Collaborating with AZ scientists or external partners to contribute to the development and optimisation of manufacturing processes for new medicines with consideration of the requirements of speed quality cost sustainabilityreproducibilityand efficiency.

• Fully competent in own research areainorder toidentifyand implement best experimental practice for generatinghigh-qualitydata inanexperimentally efficient way includingincollaboration with other technical specialists.

• Hold ascientificsupervisory role when needed but withoutlinemanagementresponsibility.

• Drive new ways of working in collaboration withtechnologyexperts to focus on data driven experimentation which willact asa cornerstonetoenable AZs modelling and simulation aspirations.

• Identification andeffectivecommunication ofprocess risks arising from scaleequipmentor process changes.

• Supporting problem solving whenissues ariseduringdevelopment or manufacturing

• Collaborating with digital experts to developdigital solutions formodelling and automationto deliver our bold strategy.

• Drive the adoption of digital solutions across the process chemistry community.

• Deriving and applying models based on experiments and the published literature to support control strategies for impurities across AZs portfolio.

Essential requirements

• PhD inphysical organic chemistry/organic chemistry with amechanisticfocusorMSc in chemistry withequivalent industrial experience.

• Experience in practical organicchemistry.

• Interest and enthusiasmforunderstandingreactionmechanismsandhowchemicalprocesses workon a fundamental level.

• Agoodunderstanding of synthetic methodologies reactionmechanismsand modern analytical techniques.

• Strong understanding of digital solutions with confidence in using them developing them with experts and a digital-first mindset.

Desirable requirements

• Lab-based pharmaceutical industry and/or process development experience using a broad range of practical techniques.

• Experience in using a wide variety of off-line analytical techniques and be able toidentifyand implement more specialist (in-line) approaches when required by liaising with analytical experts.

• Expertiseinone or more of the following areas:kinetics DoE process modelling lab automation PAT continuousprocessingorreaction monitoring.

• Python coding skills.

• Proven record of innovation through for instance authorship of papers inventor status on patents or presenting at external conferences.

• The ability to develop and analyse multiple solutions to problems.

• Experiencementoringanddrivingperformance and developmentofyour peers.

• AI literacy including the use of AI tools and machine learning models.

Skills and capabilities

• Ability to challenge innovate think critically and flexibly bringingnew solutionsand opportunities for chemical development.

• Ability to analyse and interpretcomplexchemistry problems and provide solutionswith a high attention to detail.

• Excellent communication skills with the ability to communicate across interfaces of scientific disciplines culture andexpertiseboth internally and externally.

• The ability to confidentlyparticipatein and potentially lead improvement projects.

Why AstraZeneca:

Join ourexpert teamat AstraZenecatopioneer a new future to meet global healthcare challenges.Here you will shape how science becomes supply at global scaleunexpected teams in the same room sparking bold thinking modern labs and digital platforms accelerating decisions and a shared commitment to advancing medicines with a lighter environmental footprint. You will work on constant new developments from modelling and automation to PAT and continuous processing with clear line-of-sight to patients and the chance to influence end-to-end ways of working. We value kindness alongside ambition pairing high standards with the support learning and trust needed to take smart risks and make meaningful progress.

If you are ready to turn mechanism into medicine and build scalable sustainable processes that leave a lasting impact take the next step today and show us how you will elevate our science and delivery!

Where can I find out more

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Closing Date