Director, Project Toxicologist – Immune Oncology (IO) Safety Science

Director Project Toxicologist Immune Oncology (IO) Safety Science

Location: Cambridge UK (Hybrid required 60% presence in the office)

Salary: Competitive

At AstraZeneca our bold ambition is nothing less than to eliminate cancer as a cause of death. Our pioneering pipeline of oncology medicines reflects this mission and our Immune Oncology (IO) Safety team plays a critical role in accelerating transformative therapies to patients.

We are seeking a highly motivated innovative and passionate Director ProjectToxicologistto join our IO Safety group. This role focuses on novel immunotherapeutic including immune cell engagers. Candidates with a strong Immunology and toxicology background preferably in Oncology are encouraged to apply.

You will partner with cross-functional teams across Oncology R&D bridging discovery and regulatory toxicology Immunotoxicology driving innovative safety strategies and accelerating drug development. Your expertise will inform candidate selection guide regulatory strategy and help define the future of oncology safety science.

What Youll Do

• As a core member of multi-disciplinary drug development teams you will deliver globally acceptable toxicological packages to predict assess and mitigate target and modality related safety risks to support data-driven decisions across discovery and development programs.

• You will develop and implement innovative solutions to combine regulatory toxicology with ground breaking science and technologies to progress novel drug candidates to the clinic and through development to the market in line with business needs.

• Influence project strategy and decision making communicate clear positions on integrated risk assessments in various formats including informing internal decision-making governance bodies and interacting with external health authorities.

• Deliver quality non-clinical summaries and contribute to regulatory submissions for IO projects.

• Maintain and expand expertise in regulatory standards preclinical safety and modality-specific safety science staying ahead of industry trends.

• Drive Oncology Safety science through internal and external collaborations publications and scientific leadership.

• Additional responsibilities include providing experienced non-clinical evaluation of in-licensing and out-licensing opportunities mentorship and guidance to emerging toxicologists with respect to regulatory environment and supporting their career growth and development.

Education/Experience Requirements

• DABT or PhD in toxicology or immunology (or equivalent) with several years of experience in the pharmaceutical or biotechnology industry working as a non-clinical safety lead supporting immunology and/or oncology programs with planning execution interpretation and communication of regulatory toxicology data.

• A proven understanding of drug discovery and development with a track record of delivering multiple toxicology programs supporting IND/CTA filings.

• High level of knowledge and expertise in designing toxicology strategies and delivering in vitro/in vivo and risk assessment of immune/target related risks driven by the pharmacology of IO therapeutics.

• Ability to solve problems in a goal-focused fashion with willingness to challenge conventional thinking and capacity to coordinate tasks across multiple projects and geographies.

• Excellent verbal and written communication interpersonal- and influencing skills. Adopting an inclusive and collegiate working style and a desire to drive own- and support others development. Represent AstraZeneca interests maintaining high ethical and scientific standards.

• Commitment to inclusion and diversity supporting AstraZenecas Great Place to Work objectives.

So whats next

Complete your application before the below closing date 8th September 2026

Where can I find out more

Follow AstraZeneca on LinkedIn AstraZeneca on Facebook AstraZeneca on Instagram you are ready to make a meaningful difference in cancer treatment we want you on our team.

Apply today and help us transform the future of oncology!

Date Posted

Closing Date