Computational Associate II Xavier Lab
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Posted on:
10 hours ago
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1 Vacancy
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Job Summary
General information
Location
Cambridge MA
Ref #
44586
Job Family
Research
Workplace
On-Site
Date published
07/28/2026
Time Type
Full time
Pay Range
$58000.00/yr - $80667.00/yr
Description & Requirements
The Broad Institute of MIT & Harvard is seeking a highly motivated Computational Associate II to join the Xavier Lab and Klarman Cell Observatory to provide computational support to collaborative research projects. Our group utilizes multi-omic datasetsincluding single-cell and spatial transcriptomics perturbation screens metagenomics and metabolomicsto study mechanisms driving health and disease. We are an interdisciplinary group with expertise in computational biology functional genomics microbiology and immunology.
We are seeking a biologically curious individual with strong technical expertise who is driven to turn complex multi-omic datasets into biological insights. As a Computational Associate II you will work collaboratively with other lab members as well as lead independent particular we are seeking a candidate ready to analyze single cell and spatial multi-omics datasets and interested in the development of novel methods and workflows.
We offer a collaborative and rigorous research environment with strong connections between wet and dry this position you will work closely with computational and experimental biologists including principal investigators research scientists postdocs and graduate students. You will also have opportunities to publish and present your work and interact with our collaborators at MGH MIT Harvard and the Broad Institute.
Responsibilities
- Analyze data across various internal and external collaborations (e.g. single-cellRNA-Seq single-cell ATAC-Seq spatial transcriptomics proteomics metabolomics and/or microbiome data)
- Develop enhance and maintain current and new bioinformatics pipelines
- Work with other team members and leadership to plan project requirements andtimelines shift priorities as needed and efficiently execute project tasks
- Write well-crafted maintainable scalable and performant code
- Learn new technical skills and biological knowledge as needed
- Present project progress during group meetings
- Lead projects leading to first-author publications
Qualifications
- A BS degree and a minimum of 2 years of related experience with a publication record or an M.S. in Computer Science/Engineering Biology Bioinformatics or a related field
- Python or R and knowledge of ML and deep learning methods
- Experience analyzing biological data such as experience working with single cell and/orspatial transcriptomics data
- Independence creativity and attention to detail with excellent critical thinking researchand analytical skills
- Excellent communication and interpersonal skills and the ability to work with biologistscomputational biologists data scientists and software engineers in a fast-paced highlycollaborative environment
- Demonstrated ability to carry out a variety of tasks in parallel recognize and solveproblems effectively and shift priorities rapidly
Selected Publications
- Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis
landscape of immune dysregulation in Crohns disease revealed through single-celltranscriptomic profiling in the ileum and colon
CRISPR screens decode a GLIS3-dependent fibrotic cell circuit
multiome immune cell atlas reveals complex disease drivers
structure-informed deep learning framework for modeling TCR-peptide-HLAinteractions
AI and biology: Foundation models meet human physiology and disease
expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to relevant skills experience education qualifications and other factors permissible by law.
At Broad your base pay is just one part of a comprehensive total rewards package. From day one this role offers a competitive benefits package including medical dental vision life and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program among other Broad benefits.
The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race national origin religion age color sex disability protected veteran status or any other characteristic protected by local state or federal laws rules or regulations.
Should you need a reasonable accommodation to complete the application or interview process please contact for assistance.
Required Experience:
IC
About Company
Broad Institute is a multidisciplinary community of researchers on a mission to improve human health.
