Associate Scientist Research Scientist – Upstream Process Sciences
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Job Summary
About the Role
To strengthen our Drug Substance Process Sciences team we are seeking a talented and motivated Associate Scientist / Research Scientist to support upstream process development for biologics.
You will contribute to early-stage process development process optimisation technology transfer and manufacturing support activities. Working within a multidisciplinary team you will help develop scalable mammalian cell culture processes perform process characterisation and troubleshooting studies and support the delivery of innovative protein therapeutics.
This is a laboratory-based role offering exposure to advanced cell culture technologies high-throughput platforms and bioreactor systems ranging from microscale to pilot scale.
Your Activities
Process Development & Laboratory Operations
Design plan and execute upstream process development studies with minimal supervision.
Apply QbD and DoE approaches to process optimisation and characterisation.
Perform mammalian cell culture experiments using shake flasks Ambr systems and laboratory-scale bioreactors.
Support scale-up scalability assessments process troubleshooting and technology transfer activities.
Utilise automation and high-throughput technologies to improve workflow efficiency.
Contribute to evaluation of emerging technologies and platform improvements.
Data Analysis & Scientific Communication
Analyse and interpret experimental data using appropriate statistical approaches.
Generate accurate high-quality scientific data and documentation.
Prepare technical reports protocols presentations and project summaries.
Communicate findings and recommendations to project teams and stakeholders.
Collaboration & Compliance
Collaborate with Cell Line Development Analytical Sciences Downstream Development Manufacturing and external partners.
Represent Upstream Process Sciences in cross-functional project teams.
Maintain accurate laboratory records and electronic laboratory notebooks.
Ensure compliance with HSE GMP/GSP quality systems and data integrity requirements.
Participate in continuous improvement initiatives and laboratory best practices.
Technical Skills & Experience
Experience in mammalian cell culture and biologics process development.
Hands-on experience with CHO cell culture and therapeutic protein production.
Experience operating Ambr and/or laboratory-scale bioreactor systems.
Knowledge of cell culture scale-up principles and process characterisation.
Experience applying DoE and statistical data analysis tools.
Strong scientific problem-solving and troubleshooting skills.
Experience with automation digital tools and data management systems.
Understanding of GMP data integrity and quality requirements.
Advantageous
Perfusion or ATF process experience.
Technology transfer and manufacturing support experience.
Exposure to downstream processing and integrated process development.
Required Skills:
Responsible for overseeing the strategy governance and quality of all master data (Vendors Customers Materials) ensuring its accuracy consistency and alignment with business processes across the organization. P.S. Only Europe based candidates with valid work permit apply. (Visa sponsorship is not applicable) Requirements: 10 years of experience in global data depth knowledge in Master Data Governance and Strategy Expertise in Data Quality Management knowledge in Data Integration and Architecture Change Management and Data Migration
