Associate Principal Scientist – Peptide Development Chemistry Pharmaceutical Sciences (PS)

Associate Principal Scientist Peptide Development Chemistry - Pharmaceutical Sciences (PS)

Location:Macclesfield UK

About AstraZeneca

AstraZeneca is a global science-led patient-focused biopharmaceutical company that focuses on the discoverydevelopmentand commercialisation of prescription medicines for some of the worlds most serious diseases. Butweremore than one of the worlds leading pharmaceutical companies. At AstraZeneca we are pioneering new frontiers byidentifyingand treating patients earlier working towards the aim ofeliminatingcancer as a cause of death.

Come and join our AZ team where you will play a pivotal role in this exciting period of development!!

Pharmaceutical Sciences is a function within the AstraZeneca Biopharmaceuticals R&D unit that builds innovative efficient solutions by transforming molecules into investigative medicines meeting unmet needs of future patients. Early Chemical Development (ECD) is CMC department with responsibility for early phase Drug Substance. The departments responsibilities span from early engagement with Discovery Chemistry groups to manufacture of Phase II Clinical material and its key skill areas include Analytical Chemistry Crystallisation Isotope Chemistry Large-Scale Laboratory (Kilo-Lab) Manufacturing Process Chemistry Process Design Process Engineering Route Design and Separation Science.

Werelooking for a highly experienced Process Chemist to join the team working on our peptide-containing clinical programs. These programs include pure-play therapeutic peptide projects as well as projects involving peptide conjugates (such as antibody-peptide conjugates and oligonucleotide-peptide conjugates). The role will sit within ECDs New Modalities team with a focus on delivering against our TIDES-based early clinical-phase project portfolio working closely with our CMC Project Leaders and in collaboration between our late-phase development teams and our internal Discovery TIDES colleagues. The individual will have extensive process chemistry developmentmanufacturingand project leadership experience and this must include considerableexpertisein developing peptide chemistry for CMC applications. A passion for working in new / emerging scientific areas and developing solutions to technical and project challenges is a key requirement for the role.

Key Responsibilities:

• As a project technical lead for Early Chemical Development working on complex peptide and peptide-conjugate drug projects you will drive the development and manufacture of these peptide-containing drug substances contributing significantly to the definition and implementation of manufacturing strategies for API processes driven primarily through external partnership with our CMDOs

• Demonstrate scientific leadership contribute strategicthinkingand provide expert challenge within peptide (and peptide-conjugate) drug project CMC teams whilst role modelling positive behaviours in exploring new ways of working and accelerating scientific development in both projects and the department

• Bring an outward-facing perspective towards addressing opportunities (collaborating withacross functional and departmental boundaries identifying/aligning specialist capabilitiesidentifyingand tapping intoexpertiseexternal to AstraZeneca).

• Mentor and develop colleagues supporting them in reaching their full potential.

• Enhance AstraZenecas scientific reputation by publishing research and engaging in external collaborations.

Requirements:

• Degree or equivalent scientific qualification (Mastersor PhD preferred) in a relevant field

• Deep understanding of the drug development process spanning discovery through to launch withclear evidenceofsignificant CMC projectexpertise

• Significant direct experience of peptide-specific chemical development witha track recordof delivery and creativity in leading drug substance development project work within a CMC organisation withdemonstratedability to provide influence and strategic direction deliver technical supervision (internally/externally) and provide mentorship to colleagues

• Hand on experience of conjugation chemistry involving peptide linkers or peptide targeting agents.

• Solid understanding of the regulatory environment for clinical development and supply of peptide and peptide-containing drug substance

Desirables:

• Strong leadership skills with excellent communication and strategic influencing abilityincluding experience of partnering with external CROs and CDMOs

• Strong development focus of self and others with an interest in learning about new scientific areas

• Ability to think andoperateacross functional boundaries challenge the status quo and seek opportunities for business improvement

In Office Requirement:

When we put unexpected teams in the same room we unleash bold thinking with the power to inspire life-changing -person working gives us the platform we need to connect work at pace and we work on average a minimum of four days per week from the office. But thatdoesntmeanwerenot flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Competitive salary and benefits package on offer!

The successful candidate will have access to a flexible employee benefits fund including holiday purchase and flexible time off pension contributions Share Save Plans A performance recognitionschemeand a competitive generousremunerationpackage.

Date Posted

Closing Date