ADMEDMPK Technical Expert

Are you a proactive problem solver with a passion for driving technical innovation If so we have good news as we are looking for an experienced DMPK/ADME Technical Expert to join our Analytical Metabolism and Methods (AMM) group within Product Safety. Within this role you will make a key impact in projects by delivering innovative study designs to aid our understanding of the Absorption Distribution Metabolism and Excretion (ADME) and Pharmacokinetics (PK) and/or Toxicokinetics (TK) of chemicals in mammalian toxicology species. You will work within a highly collaborative team of study managers and technical experts while applying your scientific expertise to interpret complex DMPK/ADME data for project teams directly supporting the development and registration of sustainable crop protection products.  A recent example is the registration of TYMIRIUM technology which protects crops against soil-borne pests.  Additionally you will build effective partnerships with Contract Research Organisations (CROs) directing external study execution and collaborating to resolve technical challenges to secure the timely delivery of externally placed studies. Key responsibilities will include:

• Overseeing CRO delivery: Ensuring the timely delivery of business critical data generated at CROs while being responsible for study strategy documents protocol design evaluation of data and reviewing/authorising company reports.
• Delivering technical insights: Elucidating insights from ADME and PK/TK data and reporting expert conclusions to metabolism teams.
• Applying regulatory expertise: Utilising your expert knowledge and understanding of ADME PK/TK as well as relevant global regulatory guidance documents and their implication to optimise and de-risk our study designs. Keeping abreast of changes to regulatory guidelines and requirements.
• Partnering with CROs: Independently providing technical guidance and problem-solving support to external suppliers where appropriate to facilitate transfer of technical knowledge.
• Driving continuous improvement: Leading or contributing to the creation and optimisation of new  processes technical guidance documents and report templates to improve efficiency and consistency across the team.
• Serving as a scientific contributor within the ADME PK/TK expert area providing expertise to metabolism teams and other functional areas as required.

Qualifications :

What we are looking for

• Minimum of a degree or equivalent in a biology- or chemistry-related discipline.
• Significant knowledge in the areas of DMPK/ADME with expertise in pharmacokinetics and/or toxicokinetics.
• Familiarity of global Regulatory Test Guidelines (e.g. OECD 417) relevant to ADME and toxicokinetics studies conducted to GLP standards for the registration of crop protection chemicals.
• Experience in translating complex datasets into key safety or regulatory insights to inform decision making.
• Practical knowledge of quantitative PK/TK principles including non-compartmental analysis (NCA) calculation of key PK/TK parameters.
• Proven ability to work collaboratively within diverse scientific teams (e.g. toxicologists modellers metabolism specialists) and with external stakeholders (industry contract research or regulatory agencies) to achieve project goals.
• Capability to organise prioritise and track complex scientific deliverables across multiple projects applying strong attention to detail and analytical thinking to solve problems in scientific experiments to maintain quality and delivery to agreed timelines.
• Excellent oral and written communication skills with the ability to prepare technical reports and presentations to articulate complex technical matters clearly.
• Willingness to learn and ability to apply new skills promptly.
• In-depth understanding of in vitro and in vivo xenobiotic mammalian metabolism including metabolite identification metabolic pathway elucidation and cross-species comparison would be desirable.
• Experience managing services delivered through third-party organisations ensuring quality milestone adherence and budget discipline would be advantageous.

Additional Information :

Our site

Jealotts Hill International Research Centre UK is situated in pleasant semi-rural surroundings between Bracknell and Maidenhead and is the place of work for approximately 800 Syngenta scientists and support staff. Jealotts Hill is one of the main global research and development sites and key activities include research into discovery of new active ingredients new formulation technologies product safety and technical support of our product range.

What we offer

• Extensive benefits package including a generous pension scheme bonus scheme private medical & life insurance.
• Up to 31.5 days annual holiday.
• Large campus environment.
• A position which contributes to valuable and impactful work in a stimulating and international environment.  
• The chance to work as part of a global team to address the current and future needs of the agricultural sector.
• Learning culture and wide range of training options.

Syngenta has been ranked as a top 5 employer and number 1 in agriculture by Science Journal.

Syngenta is an Equal Opportunity Employer and does not discriminate in recruitment hiring training promotion or any other employment practices for reasons of race color religion gender national origin age sexual orientation marital or veteran status disability or any other legally protected status. Learn more about our D&I initiatives here: Hill has Disability Confident certification.

We are committed to making all stages of our recruitment process accessible to all candidates and our Jealotts Hill site are a Disability Confident Level 2 Employer. Please let us know if you need any assistance or reasonable adjustments throughout your application and we will do everything we can to support you.

Remote Work :

No

Employment Type :

Full-time