Associate Director Toxicology, Immune Safety (Discovery Safety SpecialistImmunologist)

At AstraZeneca our bold ambition is to achieve disease modification clinical remission and cure for people living with immunemediated diseases. We are expanding our diverse Immunology pipeline and building leadership across multiple indications. Join our Immunology Safety team and help deliver transformative safe medicines to patients worldwide.

We are seeking a motivated and collaborative scientist to join us in Gothenburg Sweden as an Associate Director in Immune Safety. We welcome candidates with a strong immunology background who have experience drug discovery and ideally also drug development. You will contribute to the Immunology Portfolio by shaping safety strategies from early target selection through candidate selection and clinical development.

Within AstraZeneca we place a strong emphasis on talent development. You will work alongside leaders in Immunology R&D safety science pharmacology toxicology imaging pathology computational biology and translational science with opportunities to lead science and represent AZ externally.

The role

Your core responsibilities will include:

• As a core member of multidisciplinary immunology project teams you will design deliver and interpret innovative immune safety strategies to predict assess and mitigate target and modalityrelated risks across discovery and development.

• Integrate data from in vitro systems cellular immunology in vivo models omics advanced imaging and computational tools to build mechanistic immune safety assessments that guide target selection modality design and candidate optimization.

• Evaluate ontarget and offtarget related risks (including but not limited to cytokine release immunomodulation immunogenicity considerations immune cell subset perturbations) and propose risk mitigation strategies including study design refinements monitoring plans and translational biomarkers.

• Provide integrated risk assessments to influence project strategy and decisionmaking within the safety organization across R&D functions and at internal governance bodies

• Advance predictive immune safety science by contributing to development of cuttingedge methods/strategies; publish in peerreviewed journals and present at scientific meetings.

Essential qualifications

• PhD (or equivalent experience) in immunology toxicology pharmacology or related field with expertise in immune biology

• Demonstrated experience in nonclinical safety within the pharmaceutical or biotech industry spanning drug discovery and/or development with a track record of contributing to target evaluation and candidate optimization to progress preferentially immunology or immunomodulatory programs.

• Handson experience designing strategies and/or executing in vitro and/or in vivo studies relevant to immune safety (e.g. functional immune assays cytokine release immunophenotyping translational biomarker strategies); ability to interpret data in a mechanismdriven framework.

• Proven ability to evaluate safety risks build integrated risk assessments and define mitigation strategies; strong verbal and written communication skills with experience influencing crossfunctional decisionmaking.

• Collaborative teamoriented mindset with the ability to coordinate across multiple projects and geographies; commitment to high ethical and scientific standards.

Desirable experience

• Experience spanning both discovery and development phases; record of delivering toxicology programs through discovery to clinical development.

• Familiarity with regulatory toxicology requirements

• Experience with multiple modalities such as small molecules biologics (including bispecifics) antibodydrug conjugates ASOs/siRNA and protein degraders (e.g. PROTACs) with understanding of modalityspecific immune risks and targeted delivery concepts.

• Established record of scientific contribution (publications conference presentations); experience leading external collaborations and mentoring earlycareer scientists.

Why AstraZeneca

When we put unexpected teams in the same room we ignite bold thinking to inspire lifechanging medicines. Inperson collaboration gives us the platform to connect accelerate and challenge perceptions. We work on average a minimum of three days per week from the office while balancing individual flexibility. Join the team unlocking the power of what science can do. By fusing data and technology with the latest scientific innovations we are working to treat prevent modify and even cure complex diseasesand positively impact the lives of millions.

So whats next

If science is your passion and youre looking to make a greater difference for patients theres no better place to do it. We look forward to receiving your application (CV and cover letter) by May 20th 2026. Please upload your CV and cover letter as a single combined document.

Date Posted

Closing Date