PhD position in Breast Cancer and Evolutionary Therapy

We are looking for a PhD candidate who is highly motivated well-organized and dynamic with a high level of independence and creative thinking. The ideal candidate must possess a deep understanding of molecular biology an interest in breast cancer research and a willingness to actively engage in and contribute to a collaborative research environment.

The successful candidate in collaboration with a researcher working on the project will work and develop the research project UndErstandiNg Hormonal Adaptation aNd Clonal sElection supported by single cell DNA sequencing of locally advanced breast tumors using Evolutionary Therapy (ENHANCE). In addition the candidate will contribute to the academic environment by supervising a masters student associated with the project.

The physical work location will be at the Department of Medical Genetics Section for Research and early 2027 the Department will move to the Life Science building providing the applicant the exciting opportunity to work in Norways largest and most modern research building.

The successful candidate must hold a Masters degree in molecular biology genetics cancer biology or a closely related field. Prior experience or technical expertise of the candidate should be relevant to the research project in question UndErstandiNg Hormonal Adaptation aNd Clonal sElection supported by single cell DNA sequencing of locally advanced breast tumors using Evolutionary Therapy (ENHANCE) particularly in areas such as cancer biology drug resistance and evolution.

Experience in the following topics is required:

• Demonstrate experience in laboratory-based wet-lab research in breast cancer biology molecular pharmacology or related fields:
  • Hands-on experience in cell culture co-culture and drug screening
  • Practical experience in fluorescence microscopy methods image analysis and quantitative interpretation
  • Working with patient-derived organoids (PDxOs) and tissue processing
  • Molecular biology methods such as transfection methods (lentiviral siRNA etc.) western blot protein interaction assays (e.g. BRET) PCR RT-qPCR
  • Flow cytometry for single cell analysis
  • DNA/RNA sequencing
• Proven ability to develop and optimize experimental protocols based on literature
• Experience in performing trans-well interaction/migration assay
• Experience in experimental design and independent laboratory work
• Basic knowledge in scripting language (Python or R for data visualization)

Experience in the following topics will be considered an advantage:

• Experience in teaching mentoring or supervising students at the bachelors/masters level in laboratory settings
• Familiarity with sequencing workflows and downstream genomic analysis
• Experience in pharmacological/toxicology assays and experimental design
• Experience working in a multidisciplinary or international research environment
• Strong collaborative skills and ability to contribute to team-based research projects

• We are seeking a highly motivated well-organized and dynamic PhD candidate with a strong capacity for independent and creative thinking. The ideal candidate will possess a solid foundation in biology an interest in biological research and a collaborative mindset with a willingness to actively share knowledge and engage with colleagues.
  You must be able to:
  
  • Understand plan and execute the research project in a team
  • Supervise and lead bachelors and masters students
• Ability to present and execute novel ideas in method development data analysis and interpretation
• Team player who can work independently in a multidisciplinary team
• Excellent oral and written English
• Proactive flexible and problem-solving attitude
• Experience in working with deadlines and being involved in multiple projects
• Interest in developing skills required for applying for early-career research grants

• A full-time contract. A 6-month trial period will be applied.
• Salary in agreement with the current collective agreement and qualifications.
• Favourable pension arrangements.
• Possibility for extending the contract if funds are available
• A stimulating (international multidisciplinary) research environment where quality professionalism and team spirit are encouraged.
• The possibility of working on scientifically exceptional and high-impact state-of-the-art projects.
• A productive and motivating research environment. Attractive welfare arrangements.

How to apply:

• Applications only through Webcruiter are accepted.
• In the application letter please include a summary of scientific work and interest
• CV and copies of educational certificates with grades.
• Names email and telephone number of 3 referees (describe relation to applicant).
• A complete list of publications highlighting the candidates role in main publications relevant to the position.

Links:
Cancer genome variation: Science Building: KirkeveienOslo Norway