Senior Scientist, Mass Spectrometry

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About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

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We are searching for the best talent for a Senior Scientist Mass Spectrometry to be located in Spring House PA.

Purpose: The Senior Scientist Mass Spectrometry (MS) will join the Biophysics team within the Biologics Discovery (BD) this role you will serve as a scientific leader and subject matter expert in advanced structural mass spectrometry driving strategy innovation and application of MS based technologies to support discovery and optimization of protein therapeutics including multispecific antibodies and antibodydrug conjugates (ADCs).

The preferred candidate will have demonstrated scientific expertise in applying advanced mass spectrometry approaches to accelerate characterization of protein therapeutics.

You will be responsible for:

• Providing scientific leadership for protein mass spectrometry capabilities supporting biologics discovery programs.
  
• Driving structurefunction analyses and mechanistic understanding of target binding to inform lead selection engineering and optimization decisions.
  
• Designing interpreting and integrating advanced MS experiments (intact MS peptide mapping HDX-MS) to support complex discovery and developability questions.
  
• Championing the development qualification and implementation of new analytical technologies software and workflows to improve throughput data quality and scalability.
  
• Acting as a technical advisor to project teams collaborating closely with biophysics protein engineering protein expression computational biology and other discovery functions.
  
• Representing the function through internal scientific reviews governance forums and external publications or presentations maintaining a strong scientific presence for the organization.
  

Qualifications/Requirements

Education:

• PhD in Analytical Chemistry Biochemistry Biophysics or a related scientific field with 2 years of relevant experience; or a Masters degree with 5 years; or a Bachelors degree with 8 years of directly applicable experience in mass spectrometry-based protein characterization is required.
  

Experience and Skills:

Required:

• Experience in LC/MS LC/MS/MS intact protein MS and peptide mapping for biologic characterization is required.
  
• Expertise in structural mass spectrometry strategies (i.e. HDX-MS and/or Footprinting MS etc.) with a demonstrated ability to apply the technique to complex biologics and discovery stage questions is required.
  
• Experience in discovery/development of therapeutic antibodies is required.
  
• Strong proficiency with mass spectrometry data analysis software (e.g. Protein Metrics HD Examiner Proteome Discoverer) and high-quality scientific reporting is required.
  
• Ability to communicate complex data and partner effectively in highly matrixed environments is required.
  

Preferred:

• Experience with Trajan HDXThermo Orbitrap MS platforms is preferred.
  
• Hands on expertise in chemical cross linking and/or protein footprinting MS approaches is preferred.
  
• Strong publication and presentation record in structural MS or protein biophysics is preferred.
  

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation external applicants please contact us via internal employees contact AskGS to be directed to your accommodation resource.

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