Research Fellow Focused on Gene Therapies, Lindsay Lab, MGH Cardiovascular Research Center
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Job Location:
Boston, NH - USA
Monthly Salary:
Not Disclosed
Posted on:
3 days ago
Vacancies:
1 Vacancy
Job Summary
Mass General Brigham relies on a wide range of professionals including doctors nurses business people tech experts researchers and systems analysts to advance our mission. As a not-for-profit we support patient care research teaching and community service striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.
Job Summary
GENERAL SUMMARY/ OVERVIEW STATEMENT:The Lindsay Laboratory in the Cardiovascular Research Center at Massachusetts General Hospital (MGH) is seeking a motivated enthusiastic postdoctoral Research Fellow to lead an array of collaborative studies to develop gene therapies for rare genetically-triggered aortopathies and associated arteriopathies. The fellow will have a close working relationship with CVRCs Lindsay Lab and the Musolino Laboratory in the Center for Genomic Medicine. Both labs are dedicated to the development and application of innovations in gene therapy technologies for rare vascular conditions. The candidate will be expected to have experience or high capacity to learn mammalian cell culture CRISPR/Cas9 genome editing murine modeling and various molecular genetic techniques. The team will include the Principal Investigators and other faculty postdoctoral fellows and research technicians and this position we are seeking a Research Fellow with the enthusiasm to develop projects that will contribute to diverse and highly collaborative research programs. Qualified candidates please email a CV and cover letter to Dr. Mark Lindsay:
Qualifications
PRINCIPAL DUTIES AND RESPONSIBILITIES:
- Perform CRISPR-based genome editing using established protocols
- Learn organoid differentiation across varying lineages help to drive forward established and novel protocols with team leadership
- Perform molecular genomics procedures as needed (i.e. DNA/RNA extraction library production RNAseq sample archiving tissue culture etc.)
- Design execute and interpret research experiments
- Learn any number of molecular genomics techniques including single-cell RNAseq (scRNAseq) ATACseq ChIPseq HiC and other methods
- Routinely check medium reagents and plasticwares for cell culture experiments
- Maintain mouse colonies and process murine tissues for phenotypic evaluation
- Perform noninvasive and invasive hemodynamic assessments of mouse models of human disease
- Maintain laboratory notebook
- Independently follow detailed protocols while working closely with a wide range of lab members (i.e. graduate students postdocs technicians staff scientists)
- Assist in training new Research Technicians and Fellows
- Responsible for troubleshooting problems and instructing others in highly specialized techniques.
- Investigate create and develop new methods and technologies for research advancements.
- Preparation of written data reports including methodology figure preparations written description of the study in the form of manuscripts and/or progress reports.
- Contribute to research presentations at local national and international meetings.
- Oversight of laboratory technicians participating on the projects including training them and assisting them with experimental design and implementation.
- Compose and present sections of research reports.
- Organize and/or draft material for the preparation of research papers manuscripts or other documents for publication and/or presentation.
SKILLS/ABILITIES/COMPETENCIES REQUIRED:
- Ability to work independently and as a team member
- Experience in molecular genomic techniques (i.e. PCR qPCR RNAseq gel electrophoresis)
- Experience in mammalian cell culturerequired
- Interest in learning and troubleshooting new molecular biology techniques
- Familiarity with animal modeling of disease
- Excellent organizational and communication skills
- Sound interpersonal skills and the ability to supervise and train staff effectively.
- Ability to prioritize tasks set deadlines and adapt to shifting priorities in response to changing deadlines and needs of the lab.
- Ability to function with speed precision and an understanding of theory behind protocols and experiments.
EDUCATION:
M.D. or Ph.D. in biological field required. Exceptional candidates with a doctorate and an MS degree in a related field and 5 years of experience will be considered.
EXPERIENCE:
3 years of experience in a research-related field required.
SUPERVISORY RESPONSIBILITY (if applicable):
May oversee research assistants technicians technologists and students.
WORKING CONDITIONS:
Work will be performed in the Simches Research Building on the Massachusetts General Hospital main campus in Boston MA.
Additional Job Details (if applicable)
Physical Requirements
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- Crawling N/A (0%)
- Reaching N/A (0%)
- Gross Manipulation (Handling) N/A (0%)
- Fine Manipulation (Fingering) N/A (0%)
- Feeling N/A (0%)
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- Vision - Far N/A (0%)
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- Talking N/A (0%)
- Hearing N/A (0%)
EEO Statement
Massachusetts General Hospital is an Equal Opportunity embracing diverse skills perspectives and ideas we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.
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EEO Statement:
Mass General Brigham Competency Framework
At Mass General Brigham our competency framework defines what effective leadership looks like by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance make hiring decisions identify development needs mobilize employees across our system and establish a strong talent pipeline.
About Company
Patients at Mass General have access to a vast network of physicians, nearly all of whom are Harvard Medical School faculty and many of whom are leaders within their fields.
