Computational Genomics Senior Research Scientist

Job Description

We are seeking a Senior Research Scientist in Computational Genomics to join Vertexs global Data and Computational Sciences organization. This role is embedded within the Computational Genomics team and partners closely with Bostonbased research groups to design analyze and interpret human genetics genomics and sequencingbased studies that advance drug discovery and development programs across multiple therapeutic areas. The successful candidate will provide scientific leadership in the application of human genetic analyses genomics and computational biology to biological discovery target validation and mechanistic understanding. This role requires strong technical depth independent scientific judgment and the ability to translate complex data into actionable insights for crossfunctional project teams. This position is based in Boston MA and is eligible for onsite or hybrid work with an expectation of at least three days per week onsite.

Key responsibilities:

• Serve as a senior computational genomics partner to discovery and project teams acting as the primary bioinformatics and genomics subjectmatter expert for assigned programs
• Lead the design analysis and interpretation of human genetics genomics and sequencingbased studies to address key biological and translational questions
• Apply sophisticated computational and statistical approaches to analyze largescale human genetic genomic and functional genomics datasets integrating best practices and emerging methods from the field
• Distill complex analyses into clear conclusions recommendations and next steps for diverse scientific audiences including noncomputational stakeholders
• Provide scientific ownership and accountability for human genetics and genomics deliverables ensuring highquality timely outputs that support project decisionmaking
• Partner with computational and genomics method development teams to identify opportunities to improve robustness scalability and usability of internal analysis approaches
• Stay current with advances in human genetics genomics technologies and computational biology and proactively advocate for approaches that could accelerate Vertexs research programs

Knowledge and Skills:

• Experience applying computational methods and bioinformatics tools to largescale biological datasets; proficiency in R or Python Unix/Linux environments and highperformance computing systems.
• Solid grounding in statistics and genetics including the role of human genetic variation in disease biology.
• Excellent written and verbal communication skills with the ability to present complex technical concepts clearly and effectively to diverse audiences.
• Demonstrated ability to work effectively across crossfunctional teams and manage multiple priorities in a fastpaced research environment.
• A collaborative growthoriented mindset with a commitment to scientific rigor continuous learning and supporting team success.

Minimum Qualifications:

• PhD in computational biology bioinformatics genomics human genetics systems biology bioengineering or a related field with 3 years of relevant postdoctoral or industry experience; or Masters degree in a related field with 8 years of relevant industry experience.
• Demonstrated excellence in the analysis visualization and interpretation of human genetics genomic and nextgeneration sequencing (NGS) data.

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Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

In this Hybrid-Eligible role you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.

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Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race color sex gender identity or expression age religion national origin ancestry ethnicity disability veteran status genetic information sexual orientation marital status or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager or contact Talent Acquisition at