Senior Scientist, Pharmacology

About Hexagon Bio:

Hexagon Bio leverages a genomics-based platform and understanding of natural product evolution to develop next-generation antibody drug conjugates (ADCs) with novel payloads for cancer. We use data science genomics machine learning synthetic biology and automation to discover potent evolutionarily refined small molecules from microbial genomes and apply medicinal chemistry to optimize these molecules into truly transformative medicines.

Location: Menlo Park CA

Job description:

Hexagon Bio is seeking a highly skilled Senior Scientist to support the development and characterization of next-generation ADCs featuring novel natural-product payloads. This position involves hands-on laboratory execution to support in vitro to in vivo translation large data analysis to inform clinical indication and CRO management to drive efficacy and safety studies in different species. You will contribute to evaluating the promise of ADCs with first in class payloads.

The ideal candidate brings a strong foundation in cancer cell biology in vitro and vivo pharmacology an understanding of in vivo activity and exposure relationships and a demonstrated ability to think critically multi-task troubleshoot assays and interpret data.

We seek innovative and collaborative team members who thrive in fast-paced environments and are motivated by our mission to transform cancer therapeutics with first-in-class drugs.

Key Responsibilities:

• Design and execute in vitro assays to evaluate activity and potency (safety and efficacy) of ADCs with novel natural product payloads
• Design execution and interpretation of in vivo pharmacology studies to assess efficacy safety PK/PD relationships in multiple species
• Experience with computational methods to support integration and analysis of large data sets (proteomic gene expression or IHC) to drive model selection and translational research
• Develop plans for pharmacodynamic/safety assessment of tissue biomarkers and execute in vitro assays to guide model decisions

Requirements:

• PhD in Cell Biology Cancer Biology Chemical Biology or a related field.
• 3-4 years of biotech/pharma experience.
• Experience in leading CRO campaigns to completion on timelines with high quality study data
• Experience generating and analyzing experimental datasets to support in vivo and ex-vivo model selection
• Deep understanding of efficacy and PK/PD drug relationships to help guide in vivo data interpretation
• Proficiency with multicolor flow cytometry is ideal
• Experience leading safety studies is a plus
• Experience supporting ADCs or targeted oncology programs is a bonus
• Strong analytical and troubleshooting ability
• Excellent organizational communication and documentation skills
• Ability to work both independently and in cross-functional teams and to positively partner with team members to move projects to completion
• Initiative creativity and ability to thrive in a fast-paced startup environment

What We Offer:

• A flexible and dynamic work environment where you pave your own path Hexagon cultivates employees unique strengths at all levels and provides mobility across departments.
• All Hands Meetings provide an opportunity to share company and team updates. These meetings are rooted in our value of transparency. They are designed to foster a culture of collaboration curiosity and open communication.
• Rapid career advancement for driven performers.
• Access to scientific conferences throughout the year.
• A range of amenities courtesy of the Menlo Park Labs business park including shuttle gym rock-climbing wall pool sauna sports courts cafe bike lockers and free EV charging stations.
• Opportunities to engage with the Hexagon community through team-building events like our Hexagon Happy Hours and holiday parties.

Additional Information:

The salary range is dependent on the level of Scientist that is hired. The salary range for this position is $150000 - $180000. Our salary ranges are determined by role level and location. The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across California locations. Within the range individual pay is determined by work location and additional factors including job-related skills experience and relevant education or training.

Hexagon Bio is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race color ethnicity veteran status religion national origin marital status political affiliation age sex sexual orientation disability status membership in an organization or any other non-merit factors

Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation.