Pharmacology Research Scientist

Job Description

The Pharmacology group at Vertex Pharmaceuticals in San Diego is seeking a highly motivated and innovative Pharmacology Research Scientist to join our team. The successful candidate will focus on developing and applying primary tissue assays for drug discovery with a particular emphasis on ex vivo organ perfusion and nervous system models. This role also requires expertise in in vitro and in vivo assays to support the evaluation of novel therapeutic candidates and elucidation of biological mechanisms. This is an exciting opportunity to contribute to cutting-edge research in a collaborative and dynamic environment.

Key Duties and Responsibilities:

• Develop optimize and implement primary tissue assays to support drug discovery and development programs.
• Design and execute experiments utilizing ex vivo organ perfusion and nervous system models to evaluate drug efficacy distribution safety and mechanism of action.
• Conduct in vitro and in vivo pharmacology studies to complement ex vivo findings and provide a comprehensive understanding of drug candidates.
• Automate data collection and analysis processes to improve efficiency and accuracy in experimental workflows.
• Collaborate with cross-functional teams including medicinal chemistry biology toxicology and clinical development to advance projects from discovery to clinical development.
• Analyze interpret and present experimental data to project teams and senior leadership.
• Author and review study reports regulatory documents and scientific publications.
• Stay current with advancements in pharmacology ex vivo systems and related fields to incorporate innovative approaches into research programs.

Knowledge and Skills:

• Proficiency in pharmacology techniques including cell-based assays physiology animal handling dosing and tissue dissection/collection.
• Strong analytical and problem-solving skills with the ability to automate data collection and analyses and interpret complex data sets.
• Proficiency in data analysis software and tools (e.g. GraphPad Prism Spotfire MATLAB Python).
• Excellent communication and presentation skills with the ability to work effectively in a collaborative team environment.

Education and Experience:

• Ph.D. in Pharmacology Biology or a related field with 0-3 years of relevant experience or a Masters degree with 3 years of experience or Bachelors and 6yrs of experience in a pharmaceutical or biotechnology setting.
• Hands-on experience in developing and applying primary tissue assays including ex vivo organ perfusion and nervous system models.

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Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

In this On-Site designated role you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.

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Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race color sex gender identity or expression age religion national origin ancestry ethnicity disability veteran status genetic information sexual orientation marital status or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager or contact Talent Acquisition at