Principal Scientist, Computational Pathobiologist

At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at

As guided by Our Credo Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson we respect the diversity and dignity of our employees and recognize their merit.

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About Innovative Medicine:

Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at are searching for the best talent for a Principal Scientist Computational Pathobiologist to be in Spring House PA or La Jolla CA.

Purpose:
The Pathobiology Department within Preclinical Sciences and Translational Safety (PSTS) is seeking an intellectually bold highly motivated scientific leader to help shape the next generation of Computational Pathobiology.

As Principal Scientist you will do more than support scienceyou will help build the digital and analytical engine that powers our science shaping the future of translational this role you will democratize Pathobiology data and design build and deploy modern data pipelines automations and AIenabled analytics that transform multimodal nonclinical data into clear decisionready insight. You will translate complex Pathobiology questions into actionable data science challenges applying analytics visualization modeling and AI to generate mechanistically grounded adverse outcome pathways deepen understanding of on and offtarget safety findings and strengthen translational safety confidence across the portfolio.

Pathobiology brings together toxicologic and clinical pathologists immunotoxicologists and biomarker molecular and histopathology scientists to support the breadth of the J&J portfolio. This role is best suited for a scientifically grounded computational leader who thrives in cross-functional environments and can communicate effectively across experimental biology data science/data engineering/IT and leadership.

You will be responsible for:

Shape the Pathobiology Digital Transformation Vision and Strategy

• Partner closely with Pathobiology scientists and leaders across functions to identify prioritize and deliver highimpact data use cases aligned with PSTS priorities.
• Drive implementation of FAIR (Findable Accessible Interoperable Reusable) data principles through fitforpurpose metadata standards and workflows.

Build Scalable Data Foundations

• Establish workflows to ingest CRO Pathobiology data in near real time.
• Develop and implement scalable processes for data ingestion integration curation standardization and warehousing.
• Ensure robust quality governance and reproducibility practices are embedded from the ground up.

Deliver Insight Through Sophisticated Analytics Visualization & AI

• Create tools that support search interpretation reporting and scientific storytelling.
• Apply analytics intuitive visualizations and decisionfocused summaries tailored to diverse scientific and leadership audiences.
• Partner to deploy statistical machine learning and AI approaches to complex multimodal datasets.

Collaborate to achieve CrossFunctional Digital Delivery

• Collaborate across PSTS Discovery Statistics IT and Data Science teams to assess the current data and platform ecosystem
• Cocreate or guide the creation of clear practical digital roadmaps aligned with strategic priorities.

Advance Digital Pathobiology

• Enable key Digital Pathology initiatives including LIS support digital imaging hardware and software and wholeslide image repositories.
• Develop algorithms to help prioritize and screen candidate drug targets based on tissue expression data.
• Create composite measures and algorithms to identify translationally relevant blood- and tissue-based safety biomarkers.

Serve as Technical & Scientific Leader

• Act as a trusted subject matter expert in data science and engineering biostatistics and AI guiding solution selection and implementation.
• Build familiarity with and drive adoption of J&J data science tools and digital ecosystem.
• Manage stakeholders and deliver results via collaboration in matrixed organizations
• Drive AI literacy through training and education.
• Mentor colleagues and drive AI and data analytics literacy across Pathobiology and PSTS.
• Foster a culture of data quality FAIR principles and datadriven decisionmaking.

Communicate Science with Impact

• Independently interpret and communicate findings through highquality reports and presentations.
• Present insights in multidisciplinary forums.

Qualifications / Requirements:

Education:

• Minimum of a Masters degree in a relevant scientific or computational discipline is required
• PhD is preferred

Required:

• 6 years of proven experience applying data science/engineering and biostatistics to biomedical (human or animal) multimodal data.
• Fluency in programming languages: Python and/or R
• Experience leveraging agentic AI and generative AI to automate workflows derive programmatic solutions and embed biological context.
• Cloud computing and deployment experience (e.g. GCP Azure AWS Snowflake Posit Connect).
• Strong foundation in AI Machine learning and Statistics (e.g. clustering random forests SVM LLMs regression modeling and statistical inference integrative analysis AlphaFold)
• Strong understanding of scientific method and hypothesis testing
• Experience developing data visualization and dashboarding tools (e.g. Spotfire Power BI R Shiny).

Preferred:

• Familiarity with medical terminology and healthcare data standards (SNOMED CPT HL7).
• Proficiency in SAS
• Experience in the biopharmaceutical industry.
• Understanding of digital image analysis biomarkers and multi-Omics.
• Experience leading AI/automation/data engineering/dashboarding/analytics projects for immunology biomarkers digital pathology and investigative pathology.
• Publication and public speaking record

The anticipated base pay range for this position in the US is $117000 to $201250.

The Company maintains highly competitive performance-based compensation programs. Under current guidelines this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporations performance over a calendar/performance year. Bonuses are awarded at the Companys discretion on an individual basis.

Subject to the terms of their respective plans employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical dental vision life insurance short and long-term disability business accident insurance and group legal insurance.

Subject to the terms of their respective plans employees are eligible to participate in the Companys consolidated retirement plan (pension) and savings plan (401(k)).

Subject to the terms of their respective policies and date of hire employees are eligible for the following time off benefits:

• Vacation 120 hours per calendar year
• Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado 48 hours per calendar year; for employees who reside in the State of Washington 56 hours per calendar year
• Holiday pay including Floating Holidays 13 days per calendar year
• Work Personal and Family Time - up to 40 hours per calendar year
• Parental Leave 480 hours within one year of the birth/adoption/foster care of a child
• Bereavement Leave 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
• Caregiver Leave 80 hours in a 52-week rolling period 10 days
• Volunteer Leave 32 hours per calendar year
• Military Spouse Time-Off 80 hours per calendar year
  

For additional general information on company benefits please go to: job posting is anticipated to close on April 27 2026. The Company may however extend this time-period in which case the posting will remain available on to accept additional applications.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation external applicants please contact us via internal employees contact AskGS to be directed to your accommodation resource.

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