Director, Immunology Cell Therapy Discovery

Job Title:Director Immunology Cell Therapy Discovery
Location:Waltham MA

Hybrid Working: 3 days per week in the office

About the Position

AstraZeneca a global leader in biopharmaceuticals is committed to discovering and delivering innovative therapies that transform patient outcomes. We areseekingan experienced and visionary Director to join our Immunology Cell Therapy Discovery team. The role focuses on leading bothex vivoandin vivocell therapy discovery efforts underpinned by an in-depth understanding of immunological disease biology andexpertisein cell therapy (e.g. CAR-T) discovery.

Key responsibilities

• Strategic leadership: Develop and execute strategy to advance cell therapy discoveryleveragingstateoftheartex vivoandin vivocell therapytechnologies tohelpbuild a robust pipeline.

• Scientific domainexpertise:Maintaina comprehensiveuptodateunderstanding of the immunologicaldisease landscape and emerging trends to inform program direction and targetselection.

• Crossfunctionalcollaboration: Partner with discovery translational preclinical CMC and regulatory colleagues to progress programs and expand AstraZenecas immunologycell therapyportfolio.

• Team leadership: Build mentor and lead ahighperformingteam; foster a culture of innovation scientific rigor accountability and agility.

• Stakeholder engagement: Align strategies and milestones with internal and external stakeholders and consortia to accelerate delivery against R&Dobjectives.

• Compliance and governance: Ensure adherence to all applicable laws regulations and company policies related to the research and development of medicines.

• Assay and process development: Direct the development ofin vitroassays and research processes to evaluateoptimize andvalidatenovel cell therapy modalities and mechanisms.

Required qualifications

• Education: PhD (or equivalent) in Immunology Molecular or Cell Biology Bioengineering ora relatedfield.

• 5-10 years of relevant industry experience.

• Scientificexpertise:Demonstratedindepthunderstanding of immunological disease biology including B and Tcellmediatedimmunologicaldiseases such as multiple sclerosis inflammatory bowel disease rheumatoid arthritis allergy & asthma fibrosis etc.

• Leadership: Proventrack recordof leading scientific teams anddelivering onstrategic initiatives in a dynamic matrixed environment.

• Collaboration and communication: Excellent interpersonal communication andstakeholdermanagementskills across functions and organizational levels.

• Regulatory understanding: Comprehensive knowledge of the regulatory landscape for cell therapy and genetic engineering.

Preferred qualifications

• Vector and construct design: Experience designing andengineeringlentiviral retroviral or AAV vectors.

• Genetic engineering:Handsonexperience applying CRISPR or related tools to innovate and refine cell therapies.

• External network: Established relationships withinthe celltherapy genetic engineering and immunology communities.

• Publications: Strong record ofpeerreviewedpublications in vector engineering cell therapy engineering or related fields.

If you are passionate about leading and innovating in the field of immunology cell therapy we invite you to consider this pivotal opportunity at AstraZeneca. Join us in our mission to transform patient outcomes through groundbreaking scientific discovery.

The annual base pay ranges from $225208 - 337812. Hourly and salaried non-exempt employees will also be paid overtime pay when workingqualifying overtime pay offered may vary depending on multiple individualized factors including marketlocation job-related knowledge skills and addition our positions offer a short-term incentive bonusopportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles)to receive aretirement contribution (hourly roles) and commission payment eligibility (sales roles). Benefits offered included aqualified retirement program 401(k) plan; paid vacation and holidays; paid leaves; and health benefits includingmedical prescription drug dental and vision coverage in accordance with the terms and conditions of the applicableplans. Additional details of participation in these benefit plans will be provided if an employee receives an offer ofemployment. If hired employee will be in an at-will position and the Company reserves the right to modify basepay(as well as any other discretionary payment or compensation program) at any time including for reasons related toindividual performance Company or individual department/team performance and market factors.