Protein Designer

We are Arcadia Science an evolutionary biology company founded and led by scientists. Our mission is to turn natural innovations into real-world solutions by developing systematic and quantitative approaches to leveraging biology for therapeutics R&D. We share our research as openly as possible to accelerate discovery and make our work broadly useful.

Were closing the gap between biological data and biological understanding. Our Validation team does this by closing the designbuildtestlearn loop through lab validation across diverse organisms. Read more about our work through our publications.

We are seeking a Protein Designer to join our Validation this role the Protein Designer will work cross-functionally to run experimental loops aimed at validating our novel protein design tools. The scientist in this role will work to independently plan protein design projects apply our tools and their ideas to generate proteins and evaluate the biological function of the proteins they design both in vitro and in vivo.

Our ideal candidate should have deep knowledge of proteins and how they function in a cellular context as well as hands-on experience related to running designbuildtestlearn loops. They are energized by evaluating novel biology skilled at troubleshooting and thrive in collaborative and open research environments. Enthusiasm and participation in open science is also required as we routinely share our findings via our open-source pubs.

• Independently design plan and execute projects related to protein design

• Coordinate and drive design-build-test-learn loops to evaluate protein design tools

• Experimentally validate novel proteins in the lab (in vitro or in a cellular context)

• Collaborate cross-functionally with computational and experimental scientists

• Contribute to the development and improvement of analyses tools and methodologies related to protein design and the evaluation of novel proteins

• Synthesize ideas data and findings into fully open-access pubs and engage with the scientific community to maximize impact and garner feedback that improves the work

• PhD or equivalent experience in biochemistry biophysics bioengineering or related field

• At least 3 years post-PhD or equivalent experience in a related position

• Deep understanding of protein function in the cell biology and structure and how these might be useful for protein design

• Experience with validation design-build-test-learn loops or something similar

• Familiarity with SOTA protein analysis and design tools (e.g. ESM Rosetta etc.)

• Experience with protein biology biochemistry or cell biology to inform protein expression and purification assay development experimental design etc.

• Experience in at least one programming language and experience with relevant libraries

• High level of autonomy and critical thinking skills

• Written and oral communication skills and a willingness to share research openly early and often

• Experience working with cross-functional teams with different working styles and types of expertise