Vice President, Analytical Development & Quality Control

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The companys R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The companys RAS(ON) inhibitors daraxonrasib (RMC-6236) a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291) a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805) a RAS(ON) G12D-selective inhibitor; and RMC-5127 a RAS(ON) G12V-selective inhibitor are currently in clinical development. As a new member of the Revolution Medicines team you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are seeking a strategic and execution-driven Vice President Analytical Development & Quality Control (ADQC) to lead the vision strategy and execution of analytical development and QC across our growing portfolio.

Reporting to the Senior Vice President Pharmaceutical Development & Manufacturing this executive will build and scale a phase-appropriate forward-looking analytical organization that enables rapid development of small molecule programs while positioning the company for late-stage development and global commercialization.

As a key member of the PDM leadership team this role will shape analytical strategy at the enterprise level ensuring robust control strategies regulatory readiness and operational excellence across internal and external networks.

Responsibilities:

Strategic & Organizational Leadership

• Define and drive the enterprise-wide analytical development and QC strategy aligned with portfolio and corporate objectives.

• Build lead and scale a high-performing ADQC organization to support a multi-asset oncology pipeline.

• Establish a culture of scientific excellence accountability and collaboration aligned with RevMed values.

• Serve as a core member of the PDM leadership team influencing cross-functional CMC and development strategies.

Technical & Analytical Excellence

• Design and implement phase-appropriate analytical strategies including characterization specification setting and control strategies.

• Oversee impurity profiling degradant analysis comparability and lifecycle management of analytical methods.

• Ensure alignment of analytical approaches with clinical and regulatory needs enabling accelerated development timelines.

• Drive innovation in analytical technologies and approaches for complex mechanism-driven small molecules.

Quality Control & Operations

• Establish and oversee compliant efficient QC operations with strong data integrity and digital systems.

• Ensure inspection readiness and adherence to global regulatory standards (FDA EMA ICH).

• Implement scalable processes to support late-stage development and commercialization.

External Network & Partnerships

• Lead the strategy and oversight of outsourced analytical development and QC activities.

• Select qualify and manage CDMOs and contract laboratories to ensure high performance and compliance.

• Oversee method transfer validation and lifecycle management across external partners.

• Proactively manage risks timelines and quality across the external network.

Regulatory Leadership

• Provide analytical leadership for global regulatory submissions (IND IMPD NDA MAA JNDA.

• Represent ADQC in health authority interactions and inspections as needed.

Required Skills Experience and Education:

• PhD (preferred) or MSc in Analytical Chemistry Pharmaceutical Sciences or related field.

• 18 years of industry experience with significant leadership in analytical development and QC.

• Proven track record supporting late-stage development and global regulatory filings (IND/NDA/MAA/JNDA).

• Demonstrated success leading and scaling teams (10 years in leadership roles preferred).

• Deep expertise in GMP quality systems and global regulatory expectations (FDA EMA ICH).

• Extensive experience managing external analytical networks (CDMOs CTLs).

• Strong strategic thinking with the ability to make data-driven risk-balanced decisions.

• Excellent communication and stakeholder influence at executive levels.

Preferred Skills:

• Experience in oncology or targeted therapies.

• Background in accelerated or expedited development pathways.

• Experience building analytical/QC functions in a high-growth biotech environment.

• Ability to balance speed quality and risk in a dynamic setting.

  #LI-Hybrid #LI-GL1

We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms email phone or text message.

Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information purchase equipment or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @ email address.

If you believe youve been contacted by someone impersonating a Revolution Medicines recruiter please report it to so we can share these impersonations with our IT team for tracking and awareness.