Senior Scientist, Computational Protein Design

AboutAbiologics

Abiologicsis a Flagship Pioneering company developingSynteins a transformative class of fully synthetic proteins composed entirely of artificial building blocks such as D-amino acids and TMare designed to transcend the limitations of traditional biologics with improved oral stability immune evasion and metabolic durability all while being fully programmable by design.

generative designautomated synthesis andrapid experimental screeningto enable iterative optimization at scale.

Position Summary

We are seeking aProtein Design Scientisttojoin the Computational Protein Design team and helpdrivestructure-based design and optimization of synthetic proteins. This is a highly interdisciplinary role at the interface of computational design structural biology and protein engineering.

Ideal candidates have deep experience inde novo protein designminiproteins andbindersengineeringand are eager to push the boundaries of non-natural protein design in a fast-moving data-rich environment.

Key Responsibilities

• Design and executeSynteinsTMengineering campaigns to generate drug candidates.
• Create computational design strategies to deliver drug candidates drawing from array of ML tools and Rosetta scripts.
• Collaborate with computation chemistry and experimental biology teams to optimize designs for function solubility and stability.
• Integrate structural and biophysical data (e.g. binding CD HDX-MSCryoEM) into iterative optimization cycles

Qualifications

• PhD in structural biology biophysics protein design or related field
• 2 years of hands-on experience instructure-guided protein design
• Demonstratedproficiencywith modern structure prediction and design tools such asRFdiffusionproteinMPNN AF2 Boltz2BoltzGen Rosetta or equivalent SOTA tools for in-silico protein engineering.
• Strong understanding of the biophysics of protein folding and interface energetics
• Demonstrated ability to progress designs from concept to experimental testing
• Excellent communication skills

Preferred

• Experience designingminibindersor proteins <100 AAs
• Familiarity with non-canonicalamino acid design
• Familiarity with moleculardynamics tools.
• Exposure to high-throughput or automated protein engineering environments
• Prior work on platform-based or early-stage biotech teams

Why JoinAbiologics

• Help invent anew class of programmable synthetic proteins
• Be part of ahigh-velocity discovery platformwith real-time synthesis and screening
• Collaborate with a deeply interdisciplinary mission-driven team
• Redefine the limits of what proteins can do

ABOUT FLAGSHIP PIONEERING:

The salary range for this role is $146000 - $209000. Compensation for the role will depend on a number of factors including a candidates qualifications skills competencies and experience. Abiologics Inc currently offers healthcare coverage annual incentive program retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Abiologics Incs good faith estimate as of the date of publication and may be modified in the future.

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