Director of Statistical Science – Global Medical AffairsPayer Biometrics

Location: Barcelona - Spain (3 days working from the office and 2 days working from home).

Do you have a passion for sciencestatisticsand leadership Are you up for the challenge toimpacta company that follows the science and turns ideas into life changing medicines If yes we welcome you to join AstraZeneca!

At AstraZeneca we put patients first and strive to meet their unmet needs worldwide while applying leading edge approaches to science across many business areas. Working here means being entrepreneurial thinking big and working together to make the impossible a reality. If you are swift to act confident to lead willing to collaborate and curious about what science can do thenyoureour kind of person.

We hope that you are our newDirectorofStatistical Sciencewho canjoinus toplay an important part in our growingGlobal Medical Affairs/Payer Biometrics statistics groupwhich sits within Oncology Biometrics. This role combines individual statistical design and strategic contributions with the opportunity to lead manage and develop asmallgroup of Statisticians.

TheDirectorofStatistical Sciencereports to the Head of GMA/Payer Biostatisticsandwillbe responsible forthedelivery of services to the groups two key stakeholders GMA and Oncology Market Access and Pricing (OMAP). For GMA the groupprovides statistical support forinterventional andReal WorldEvidence (RWE) studies including developing design options and providing high quality decision support. For OMAP the group provides statistical support for the Global Oncology Payer Function via the application of quantitative skills to support decision-making processes and value demonstration including contributing to Health Technology Assessment (HTA) submissions.

What you will do:

As aDirectorofStatisticalScienceyou will line manage and develop a team of statisticians. You will be expected to:

• Take on a leadership role and drive statistical thinking in cross-functional team projects.

• Lead manage and develop a global group of statisticians ensuring the successful delivery of projects while also considering the development needs of the team.

• Contribute to strategic planning and quantitative decision making.

• Participate in adapting and developing statisticalmethodology.

• Contribute to development of new procedures and standards to increase quality efficiency and effectiveness.

• Influence key stakeholders and governance

• Act as a technical expert in interactions with external providers and collaborators.

• Work with regulatoryand payeragencies e.g. attending meetings answering questions.

• Provide mentoring to more junior staff and present at internal training seminars.

Essentialqualifications and experience include:

• MSc or Ph.D. Statistics Biostatistics or Mathematics (containingasubstantialmathematicalcomponent).

• Experience of leading projects and people in a pharmaceutical or CRO environment.

• Publication experience and/or experience of presenting at external meetings (e.g. ISPOR PSI)

Desirablequalifications and experience include:

• Programmingexpertisein RWinBugsand/or SAS.

• Experience ofreimbursement submissionsin key markets (e.g. UK and Germany.).

• Regulatory submission experiencein key markets (e.g. EU and USA.)

• Application of indirect comparisonmethodology(e.g. Bayesian/Frequentist NMA and MAIC/STC methodologies).

• Experience of performing adjustment for treatment switching/cross-over within clinical trials (e.g. RPSFT and IPCWmethodology.).

• Analysis of health utility data including mapping and value set application.

• Application of causal inference models to clinical trial and RWE data.

• Experience of working with RWE datasets and registries (e.g. Flatiron.).

Why AstraZeneca

Its a place to think differently to find new ways of handling and treating diseases. We are trusted and empowered to explore.Ultimately itsmore than a job. We know that our work impacts people with serious conditions many of whom have no other alternatives.Thatswhat drives us the potential toimpactover one billion patients worldwide.

When we put unexpected teams in the same room we unleash bold thinking with the power to inspire life-changing -person working gives us the platform we need to connect work at pace and challenge perceptions. Thats why we work on average a minimum of three days per week from the office. But that doesnt mean were not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Are you ready to make a difference Apply now and join us in our mission to change lives.