Director, In Silico Discovery, EU CADD

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Location: Belgium (Beerse) (Hybrid)

Position Overview

We are seeking a creative selfmotivated leader to elevate the impact of our portfoliofacing CADD team. You proactively see opportunities to improve discovery decisions across the portfolio. You will drive programs toward NMEs by strengthening partnerships across portfolio and global discovery chemistry teams and rapidly growing the impact of innovative computational design in smallmolecule this role you will guide the European CADD team in Beerse Belgium and Toledo Spain in applying both commercial and internally developed software solutions across the Johnson & Johnson portfolio. You are a highly collaborative leader passionate about advancing smallmolecule design through computational innovation. This position offers the opportunity to join a diverse global community of computational scientists dedicated to delivering transformative medicines to patients.

As a Director in our global CADD organization you will lead a highperforming team of portfoliofacing CADD scientists to drive the strategic application of computational design across our smallmolecule portfolio. With a vision of predict first you will partner closely with portfolio teams and the broader In Silico Discovery organization to ensure the most effective AI/ML and computational methodologies are deployed to accelerate programs toward NMEs.

You will play a pivotal role in crafting our discovery strategies leading crossfunctional collaboration championing change and representing our work externally. Reporting to the Senior Director of In Silico Discovery Global CADD you will help advance innovation across a wide range of modalities while developing and empowering a strong cohesive team.

If you excel in building highperforming teams thrive in a fastmoving and innovative environment and are passionate about the impact computational approaches can have on drug discovery we invite you to join us in bringing transformative therapies to patients worldwide.

Primary Responsibilities

• Lead portfolio-facing CADD teams across European sites (Beerse Belgium and Toledo Spain) aligning support with portfolio priorities and ensuring high-quality delivery.

• Partner across In Silico Discovery to align resourcing and engagement increasing impact across Janssens portfolio programs.

• Set the computational design innovation strategy across modalities (e.g. small molecules degraders RIPTACs molecular glues peptides siRNA) to keep the portfolio at the forefront of predict first discovery.

• Drive computational chemistry design and optimization using commercial and internal computational and AI/ML tools building a predict first capability with Global Discovery Chemistry and ISD partners.

• Coach and develop CADD scientists and people leaders supporting performance management and meaningful career growth in a matrix environment.

• Represent In Silico Discovery externally through consortia publications and conference participation as needed.

• Co-lead external innovation partnerships to advance ISD and enterprise priorities; evaluate build/buy/partner options including due diligence for partnering or M&A opportunities.

• Oversees the creation of models such that models are scalable and reusable for multiple use cases and across functions and geographies.

• Foster a scientifically rigorous inclusive and collaborative culture focused on continuous learning and innovation.

• Proactively creates a purpose driven environment by aligning Johnson & Johnsons Credo and Leadership Imperatives with the strategies and goals of the team and enterprise.

• Communicates strategically to highlight In Silico Discovery initiatives activities and achievements that bring positive visibility to the organization.

Professional Experience and Qualifications

Required:

• A PhD and a minimum of 10 years of experience in drug discovery with industry or related leadership experience.

• Hybrid role in Beerse Belgium; with a regular on-site presence in Beerse Belgium to lead the EU CADD team in Beerse Belgium and Toledo Spain.

• Travel of 20% or more of the time may be required both between the two EU sites and to our US sites.

• Demonstrated expertise in the field of applied computation and small molecule drug discovery is required.

• Deep understanding of pharmaceutical discovery and optimization processes.

• Deep understanding of advancing initial hits for targets on the path to and including NMEs (new molecular entities entering development).

• Demonstrated experience in developing and applying methods in small molecule modalities such as peptides degraders molecular glues proximity inducers or other small molecule modalities.

• Proven experience building teams mentoring and managing peoples career progression.

Preferred:

• Experience in generating data visualizations in tools (e.g. Spotfire Vortex Tableau DataWarrior etc.).

• Demonstrated experience in a range of small molecule modalities (e.g. traditional SM BRo5 degraders RIPTAC GLUE peptides) is preferred.

• Hands-on experience with large scale data curation aggregation manipulation integration mining and analysis including structured and unstructured data sources.

• Demonstrated experience across multiple small molecule modalities drug discovery protein targets and therapeutic areas.

• Ability to organize and communicate complex data sets in a clear and concise manner to key stakeholders from diverse backgrounds

• Prior experience working with or leading collaborations with external academic biotechnology and contract research organizations.

• Strong publications patents and/or proven record of supporting discovery of clinical/pre-clinical candidates.

• Strong motivation passion and commitment to science and patients.

• Availability to travel up to 20% yearly is preferred (international as well as domestic)

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation external applicants please contact us via internal employees contact AskGS to be directed to your accommodation resource.

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