Senior Expert Science & Technology – Downstream Process Modelling

Job Description Summary

Job Description

In this role you will:

• Develop and apply downstream process models for biologics with a strong emphasis on
• chromatography (e.g. IEX HIC MMC affinity) and their underlying physicochemical principles.
• Extend modelling approaches to other downstream unit operations (e.g. filtration UF/DF viral inactivation) and connect individual steps into integrated DSP models to support process understanding and optimization.
• Design plan and execute laboratory experiments to generate highquality data for model development calibration and validation working handson in the lab when required.
• Use modelling to support process design scaleup troubleshooting robustness studies and decision making across early and late development.
• Implement and deploy models using Python including development of userfriendly tools or apps that enable broader adoption by project teams and stakeholders.
• Translate complex modelling results into clear actionable insights for multidisciplinary audiences including process scientists project leaders and management.
• Collaborate and communicate effectively with internal and external stakeholders ensuring alignment between modelling activities experimental work and project objectives.
• Actively contribute to and help shape the global modelling community sharing best practices methodologies and innovations across sites and functions.
• Contribute to scientific documentation technical reports and regulatoryrelevant deliverables as required.

What you will bring

Education & experience

• MSc PhD or equivalent experience in Biotechnology Chemical Engineering Biochemistry or a related field.
• Several years of experience in biologics downstream process development with demonstrated focus on process modelling.
• Strong handson expertise in chromatography including mechanistic understanding of separation phenomena.

Technical expertise

• Proven experience in downstream process modelling ideally including chromatography modelling parameter estimation scaledown/scaleup concepts and integration of multiple unit operations.
• Ability to design and run experiments to support model development and validation.
• Strong programming skills in Python with experience in building reusable tools workflows or applications for broader user groups.
• Familiarity with data analysis visualization and model deployment concepts is a strong advantage.

Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding inclusive work environment and diverse teams representative of the patients and communities we serve.

Accessibility and accommodation
Novartis is committed to working with and providing reasonable accommodation to all individuals. If because of a medical condition or disability you need a reasonable accommodation for any part of the recruitment process or in order to receive more detailed information about the essential functions of a position please send an e-mail to and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Skills Desired