Senior Scientist II, Precision Medicine TA
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Job Location:
Waltham, MA - USA
Monthly Salary:
Not Disclosed
Posted on:
2 hours ago
Vacancies:
1 Vacancy
Job Summary
The Precision Medicine Department is committed to advancing drug development and patient care by deepening our understanding of disease biology and creating personalized treatment tools. Within the Precision Medicine Immunology group our translational research team utilizes cutting-edge technologies to study immunology identify biomarkers and validate drug mechanisms across AbbVies Immunology pipeline. We are seeking a highly motivated Senior Scientist II with a strong background in immunology or immune-oncology and a passion for translational research to join our team. This individual will lead the development of clinical biomarker strategies and assays for inflammatory and autoimmune diseasesincluding Dermatology Gastroenterology Rheumatology and Fibrosisspanning late discovery through clinical trials. The successful candidate will collaborate within interdisciplinary teams independently design and execute experiments troubleshoot challenges and interpret results to advance translational and biomarker research. Expertise in advanced molecular techniques flow cytometry and evaluation of drug target engagement receptor occupancy pharmacodynamics as well as experience with human tissue and disease/drug biology is essential for this role.
Key Responsibilities:
Lead biomarker strategies within cross-functional teams to identify gaps and develop fit-for-purpose clinical TE/PD predictive and exploratory biomarker assays supporting human dose projection early efficacy assessment and patient selection in clinical trials.
Collaborate with Data Science and Precision Medicine leads to analyze internal and external omics data interpret disease heterogeneity/endotypes and generate patient selection and combination hypotheses for preclinical studies.
Develop preclinical patient-derived disease models and design controlled studies to elucidate drug target mechanisms progress PD biomarker development and assess biomarker and combination hypotheses.
Serve as a subject matter expert in translational research methodologies including single-cell/spatial omics proteomics methylomics metabolomics genomics NGS MSD ELISA Luminex flow cytometry ex vivo and organoid culture.
Provide training troubleshoot assays and introduce innovative technologies within AbbVie.
Oversee external CROs and academic collaborations managing study proposals budgets timelines and data review.
Manage and coach translational scientists to ensure successful execution of research plans across multiple projects.
Stay current on advances in inflammatory and immune diseases through literature review conferences and consultation with KOLs.
Qualifications :
Qualifications
Major or advanced degree in Immunology cell & molecular biology pharmacology pathology bioinformatics or other relevant biological sciences. B.S. ith 12 years M.S. with10 years Ph.D. with 4 years of relevant industrial biotechnology experience.
Experience in leading translational medicine in gastrointestinal diseases (UC CD) is a plus.
Expertise in a broad range of translational technologies data analytics and computational tools.
Proficient in multi-parameter flow cytometry including spectral flow cytometry and analytical software (e.g. BD FACSDiva Flowjo OMIQ) to analyze different immune cell types and cell states from mice human and cynomolgus monkey.
Experienced in designing and conducting single cell omics spatial omics genomic-based assays and developing analytical workflow to generate or validate biomarker hypotheses.
Knowledgeable with integrative analysis of multi-dimensional datasets using bioinformatics tools and methods (e.g. R Python SQL AI/ML HPC and cloud environments)
Strong project leadership and organizational skills to prioritize tasks and allocate resources to meet projects goals in a tight timeline.
Experienced in managing CROs and collaborators facilitating meetings and working independently and collaboratively with multi-functional teams in a dynamic and fast paced environment.
Demonstrated ability to supervise and coach direct reports.
Excellent communication presentation organizational and people management skills
Strong track-record of scientific publications from peer reviewed journals and presentations in major conferences
Additional Information :
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more visit & Puerto Rico applicants seeking a reasonable accommodation click here to learn more:
No
Employment Type :
Full-time
Key Skills
About Company
AbbVie is a global biopharmaceutical company focused on creating medicines and solutions that put impact first for patients, communities, and our world. We aim to address complex health issues and enhance people's lives through our core therapeutic areas: immunology, oncology, neuro ... View more
