Clinical Genomics Assistant
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Job Location:
Cambridge, MA - USA
Monthly Salary:
Not Disclosed
Posted on:
3 hours ago
Vacancies:
1 Vacancy
Job Summary
General information
Description & Requirements
The Broad Institute of MIT and Harvard is one of the worlds leading biomedical research institutes. It seeks to discover the molecular basis of major human diseases develop effective new approaches to diagnostics and therapeutics and disseminate discoveries tools methods and data openly to the entire scientific community. Founded in 2004 the Broad Institute includes faculty professional staff and students from throughout the MIT and Harvard biomedical research communities with collaborations spanning the globe.
We are seeking motivated individuals to work in a cutting-edge environment to serve as a clinical genomics assistant jointly for the Clinical Genome Resource (ClinGen) and the Broad Clinical Laboratory LLC (BCL).
ClinGen is an NIH-funded program that is building authoritative resources to define the clinical relevance of genes and variants for use in precision medicine and research ( BCL is a CLIA licensed CAP accredited clinical laboratory providing physicians and physician-researchers with high quality molecular tests ( position would begin with training within our variant and gene-curation teams which support variant classification and gene-disease validity assessment in the clinical laboratory and ClinGen followed by supporting an array of BCL tests (including germline whole genome) and ClinGen disease-specific Expert Panel activities and affiliated projects within ClinGen and at the Broad Institute of MIT and Harvard.
Principal Duties and Responsibilities:
- Support ClinGen curation activities
- Research the significance of variants and genes through literature and data review
- Classify variant- and gene-disease associations
- Support research projects that require curation of genomic knowledge
- Support the BCL clinical interpretation team
- Assist with variant and gene curation activities related to the analysis of genome data and/or test development using existing and newly-developed analysis tools
- Provide project management support including tracking of cases communication with providers and weekly task tracking updates
- Assess maintain and improve variant annotation and filtration capabilities
In addition the CGA should possess excellent organizational skills and the ability to interact effectively with a local team at the Broad Institute and an international network of laboratories disease experts and data sources and balance and manage multiple tasks and projects independently. The ClinGen team is part of the Translational Genomics Group (TGG The TGG supports the use of genomics in medicine by focusing on community-centered projects that promote collaboration data sharing and open science. The TGG is led by Heidi Rehm and consists of high-impact projects such as the Center for Mendelian Genomics co-led by Anne ODonnell-Luria and the gnomAD project co-led by Mark Daly. The BCL team is part of the Genomics Platform and is led by Niall Lennon. This is an opportunity to play a role in large-scale genomics informatics and disease genetics as well as contribute to the development and implementation of transformative new clinical tests that could impact patients on an individual basis. The CGA will engage regularly with genetic counselors involved in both ClinGen and BCL activities as well as periodic networking opportunities with the wider genetic counseling community at the Broad Institute.
Qualifications:
- Bachelor of Arts (BA) or Bachelor of Science (BS) degree in a scientific field with a strong preference for coursework in genetics or molecular genetics
- Excellent written and verbal communication skills
- Required ability to work across our Cambridge and Burlington locations
- Start date: ASAP or by May or June 2026 with a minimum of a two-year commitment
This role will be a hybrid position with an expectation of a minimum of 2-3 days physically in the office.
The Broad Institute will not offer visa sponsorship for this opportunity.
Required Experience:
Junior IC
Key Skills
- CSS
- Cloud Computing
- Health Education
- Actuary
- Building Electrician
About Company
Broad Institute is a multidisciplinary community of researchers on a mission to improve human health.
