Scientist II Pilot (all genders)

Toulouse - France

Monthly Salary: Not Disclosed

Posted on: Yesterday

Vacancies: 1 Vacancy

Job Summary

Were excited to share this opportunity is part of theSandozacquisition of Just-Evotec Biologics in Toulouse. Through this opportunity you will impact the lives of hundreds of millions of people through bold ideas supported by an inclusive agile company culture. Join us to help make healthcare fairer and faster help us to pioneer access to medicine!Click to learn more.

Location : Toulouse France

Type of contract : Permanent

WhatYoullDo:

Pilot-Scale Operations & Execution:

Prepare and run pilot scalesingle usebioreactors and related equipment and provide operational support on bioreactor specifications operation process parameters

Execute and support pilot-scale upstream unit operations including bioreactor runs up to 50 L for engineering scale-up and material generation batches.

Translate laboratory-scale upstream process parameters into pilot-scale execution under guidance ensuring process robustness reproducibility and data integrity.

Support pilot activities that bridge process development and cGMP manufacturing including preparation for tech transfer.

Study Support & Cross-Functional Collaboration:

Collaborate closely with DSP pilot USP development Analytical and Manufacturing teams to support pilot-scale material generation for process characterization equipment qualification and other material generation (e.g. toxicology stability).

Participate as an upstream pilot representative on cross-functional project teams contributing to planning and execution aligned with project timelines.

Facility & Operational Readiness:

Support day-to-day pilot operations including equipment setup preparation cleaning and turnover.

Ensure activities are conducted in compliance with safety quality and operational standards.

Assistwith scheduling and readiness activities in coordination with senior team members.

PilotOptimization & Technology:

Collaborate in the technical definition of projects ofintroduction ofnew technologiesand equipment.

Supportprocess improvement and process optimizationof intensified or advanced upstream processes including the use of single-use systems and automation tools.

Collectanalyze review and interpret pilot-scale process data to support process understanding and improvement.

ConductkLa(oxygen transfer) studies to characterize bioreactor performance assess mass transfer capabilities and support process transfer across scales and equipment types.

Lead and contribute toscaleup activities ensuring robust translation of upstream processes from laboratory/pilot scale to manufacturing scale using engineering principles (e.g.kLa P/V tip speed mixing time).

Evaluate new bioreactors including characterization of hydrodynamics mass transfer mixing performance and compatibility with existing upstream processes and facility constraints.

Documentation & Compliance:

Accurately document pilot operations process data and observations in batch records protocols and reports.

Author and review SOPs protocols and technical reports under guidance.

Support deviation documentation and investigations as needed.

Technical Contribution & Knowledge Sharing:

Act as a technical contributor for upstream pilot execution including scale-up principles and process control strategies.

Support preparation of tech transfer documentation to manufacturing.

Communicateclearly andeffectively with cross functional and externalstakeholdersaboutpilot studyobjectives execution status and results clearly to project teams and management.

Training & Team Support:

Mentor and supporttraining of junior staff and technicians on pilot-scale USP operations safety practices and standard procedures.

Promote a strong culture of safety data quality and scientific rigor.

Vendor & Equipment Support:

Initiate andsupport interactions with equipment vendors and engineering teams for equipment setup troubleshooting and optimization.

Who You Are:

Mastersin engineering Biochemistry Biology or related field with 5 years of experience or Ph.D. in Engineering Biochemistry Biology or related field.Bachelors with more than 10 years of experience.

ProficiencyinUSP(cell culture) protein chemistry and bioprocess engineering

Hands-onexperience in pilot-scale bioreactor operations (10200 L).

Expertise inscale-up principles process control and data interpretation for both upstream and downstream processes.

Experience supporting engineering batches material generation and technology transfer to cGMP manufacturing.

Experience working in or supporting a cGMP or cleanroom environment(job isina non-GMPenvironment).

Familiarity with process and equipment qualification (IQ/OQ/PQ).

Understanding ofprocess safety and risk assessment principles in pilot-scale bioprocessing.

Proficiencyin both verbal and written English is essential.

Pluses

Experience in biosimilar orbiologicsdevelopment programs is an advantage.

Experiencein productionof monoclonal antibodies is a plus

Excellent attention to detail able to stay organized and relaxed in complex situations while keeping track of multiple tasks and data.

WhySandoz

Generic and Biosimilar medicines are the backbone of the global medicines industry.Sandoz a leader in thissectorprovidedmore than900 million patient treatmentsacross 100 countries in 2024and while we are proud of this achievement wehave an ambition todo more!

With investments in new development capabilities state-of-the-art production sites new acquisitions and partnerships we have the opportunity to shape the future ofSandozand help more patients gain access to low-cost high-quality medicines sustainably.

Our momentum and entrepreneurial spirit is powered by an open collaborative culture driven by our talented and ambitious colleagues who in return for applying their skills experience an agile and collegiate environment with impactful flexible-hybrid careers where diversity is welcomed and where personal growth is encouraged!

The future is ours to shape!

FR : Dans le cadre de sa politique Diversité Evotec étudie à compétences égales toutes les candidatures dont celles des personnes en situation de handicap.

ENG : In the frame of our Diversity policy Evotec considers with equal competences all applications including people with disabilities.

Required Experience: