Postdoc in Generative AI for GPCR-Targeting Therapeutic Design DTU Bioengineering

Migraine affects more than 15% of the global population and remains inadequately treated despite advances in biologics and receptor-targeting therapies. Emerging computational approaches are transforming how next-generation biologics are discovered and engineered.

We are launching an ambitious research program centered on AI-driven generative protein design to develop GPCR-targeting recombinant minibinders for migraine-associated receptors. The project aims to advance deep learningbased molecular generation and structure-guided design for therapeutic innovation.

We seek a highly motivated Postdoctoral Researcher with a strong computer science background and demonstrated expertise in deep learning and generative model development to lead the AI component of this initiative.

Responsibilities and qualifications
You will lead the computational and AI-driven aspects of the project.

Your responsibilities will include:

• Designing and implementing state-of-the-art deep learning architectures for protein generation
• Developing and optimizing generative models for de novo minibinder design
• Integrating structural biology data into AI pipelines for receptorligand interaction modeling
• Fine-tuning large protein language models for GPCR-target specificity
• Developing scalable training pipelines using modern ML frameworks
• Benchmarking model performance and implementing evaluation metrics for structure binding and stability prediction
• Collaborating closely with experimental researchers for iterative model refinement
• Publishing high-impact research at the intersection of AI and molecular design
• Supervising students contributing to computational model development

The position is primarily computational and AI-driven with close interdisciplinary collaboration.

Qualifications
We are looking for a candidate who:

• Holds a PhD in Computer Science Machine Learning Artificial Intelligence Computational Biology or a closely related field
• Has strong theoretical and practical experience in deep learning
• Has hands-on experience developing generative models
• Is highly proficient in PyTorch and/or JAX
• Has experience training large-scale neural networks on HPC or GPU clusters
• Has experience with representation learning and sequence or structural modeling
• Has a strong publication record in relevant AI/ML venues or interdisciplinary journals
• Demonstrates the ability to work independently and drive technical innovation

It will be considered an advantage if you have:

• Experience with protein language models (e.g. ESM ProtT5)
• Experience with structure prediction frameworks
• Experience in geometric deep learning or graph neural networks
• Familiarity with computational drug discovery or molecular modeling
• Experience with MLOps reproducibility pipelines or scalable AI systems

As a formal qualification you must hold a PhD degree (or equivalent).

We offer
DTU is a leading technical university globally recognized for the excellence of its research education innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

The period of employment is 3 years.

Starting date is 1 May 2026 or according to mutual position is a full-time position.

You can read more aboutcareer paths at DTU here.

Further information
Further information may be obtained from Associate Professor Timothy P. Jenkins ()

You can read more about DTU Bioengineering at

If you are applying from abroad you may find useful information on working in Denmark and at DTU atDTU Moving to Denmark.

Application procedure
Your complete online application must be submitted no later than 16 March 2026 (23:59 Danish time).

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply please open the link Apply now fill out the online application form and attach all your materials in English in one PDF file. The file must include:

• Application (cover letter)
• CV
• Academic Diplomas (MSc/PhD in English)
• List of publications

Applications received after the deadline will not be considered.

All interested candidates irrespective of age gender disability race religion or ethnic background are encouraged to apply. As DTU works with research in critical technology which is subject to special rules for security and export control open-source background checks may be conducted on qualified candidates for the position.

The Department of Biotechnology and Biomedicine (DTU Bioengineering) is an international leader in the areas of biotechnology and biomedicine. Our engineering approach to all aspects of biotechnology and biomedicine positions us as a valuable player with unique competences in a growing bio-based economy and with health systems transforming towards personalized medicine. We have a clear focus on the needs in the life science- and biotech industries and point towards innovation new businesses and scientific services for the benefit of society. The department has extensive collaborations with national and international research units and industry. DTU Bioengineering has approx. 400 employees of which 2/3 are scientific staff. The department is located at DTU Lyngby Campus.

Technology for people
DTU develops technology for people. With our international elite research and study programmes we are helping to create a better world and to solve the global challenges formulated in the UNs 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13500 students and 6000 employees. We work in an international atmosphere and have an inclusive evolving and informal working environment. DTU has campuses in all parts of Denmark and in Greenland and we collaborate with the best universities around the world.