Executive Medical Director, Hematology
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Job Location:
Boston, NH - USA
Monthly Salary:
Not Disclosed
Posted on:
30+ days ago
Vacancies:
1 Vacancy
Job Summary
Executive Medical Director Clinical Development Hematology
Location:
Boston MA
Role overview
Senior medical leader overseeing 2 hematology programs from IND through Phase 3 (first-in-human proof-of-concept registrational) under the Therapeutic Area Head.
Provides medical leadership and mentorship to Medical Directors and Clinical Development Scientists; may serve as medical monitor.
Shapes therapeutic area and regulatory strategy; represents Clinical Development in global governance (GPT/GMT) and supports business development due diligence.
Therapy area focus
Rare hematologic and complement-mediated disorders (e.g. PNH aHUS cold agglutinin disease immune-mediated cytopenias bone marrow failure syndromes).
Deep expertise in hematologic pathophysiology complement/coagulation biology thromboinflammation hemolysis and relevant biomarkers (e.g. LDH bilirubin haptoglobin reticulocyte count CH50/AP50 sC5b-9 Ddimer platelet counts).
Key responsibilities
Lead clinical strategy trial design and endpoint selection (e.g. transfusion avoidance hemoglobin stabilization hemolysis control thrombotic event rates organ protection PROs health resource utilization).
Direct cross-functional collaboration with Translational Medicine Clinical Pharmacology and Biostatistics on PD readouts exposureresponse hierarchical testing and multiplicity strategies; serve as medical expert for study teams and supervise medical monitors as needed.
Define and manage product benefitrisk; oversee safety characterization relevant to hematology (e.g. infection risk with complement inhibition cytopenias bleeding/thrombosis) and partner with Safety on risk management plans (e.g. vaccination/prophylaxis REMS where applicable).
Drive external engagement with KOLs patient advocacy groups ASH/EHA and transfusion networks; lead advisory boards; align programs with evolving orphan/rare disease regulatory pathways.
Represent Clinical Development at governance and review committees; lead scientific communications and clinical components of regulatory and scientific documents (protocols charters CSRs CTD clinical sections white papers regulatory responses publications).
Monitor scientific competitive and regulatory landscapes; integrate insights into clinical development plans and asset strategies.
Support business development activities (due diligence research collaborations) and selection of advisory board experts.
Interpret complex hematology labs and biomarker kinetics to inform dose selection go/no-go decisions subgroup analyses and regulatory narratives.
Qualifications
Required: MD (or equivalent); 7 years clinical development experience with global regulatory and product development exposure; proven track record designing and executing multinational trials; experience preparing for and attending FDA/other agency meetings; demonstrated leadership of crossfunctional teams and support for BD activities.
Strongly preferred: Board certification or substantial clinical training in Hematology or Hematology/Oncology; expertise in rare hematologic diseases or complement/coagulation biology; authorship of hematology protocols and regulatory documents; engagement with hematology-focused regulators and participation in ASH/EHA scientific forums; familiarity with hematology-specific endpoints biomarkers and risk mitigation (e.g. meningococcal vaccination with complement inhibition).
Desirable: PhD or advanced training; advanced therapy-area knowledge with ability to interpret and represent program-level data.
Work environment
Office-based role requiring ability to use a computer and digital communications collaborate cross-functionally problem-solve and maintain availability during standard business hours.
The annual base pay for this position ranges from 323216.00 - 484824.00 USD Annual. Base pay offered may vary depending on multiple individualized factors including market location job-related knowledge skills and addition our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles)to receive a retirement contribution (hourly roles) and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program 401(k) plan; paid vacation and holidays; paid leaves; and health benefits including medical prescription drug dental and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired employee will be in an at-will position and the Company reserves the right to modify base pay(as well as any other discretionary payment or compensation program) at any time including for reasons related to individual performance Company or individual department/team performance and
Date Posted
02-Mar-2026Closing Date
28-Jun-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and furtherance of that mission we welcome and consider applications from all qualified candidates regardless of their protected characteristics. If you have a disability or special need that requires accommodation please complete the corresponding section in the application form.
Required Experience:
Director
Key Skills
About Company
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, ... View more
