Senior Director Physician, Cardiovascular Safety Knowledge Group Expert, AZ ECG Centre Cardiologist

Göteborg - Sweden

Monthly Salary: Not Disclosed

Posted on: 9 hours ago

Vacancies: 1 Vacancy

Job Summary

The Senior Director Physician job in the Cardiovascular Safety Center of Excellence and SKGs involves two roles: Cardiologist at the AZ ECG Centre (delivering the cardiology scientific and operational tasks in the ECG Core Laboratory) and Cardiovascular Safety Knowledge Group Expert in the CV Safety Knowledge Group (CV SKG) advising drug/biologics teams on issues related to drug/biologics-induced CV toxicity. The clinical Cardiovascular Safety Knowledge Group (CV SKG) Expert manages a diverse range of activities related to monitoring diagnosis and mitigation of drug/biologics-induced cardiovascular toxicity in a matrix environment. The role holder inspires manages and leads cutting edge drug/biologics-induced CV toxicity projects on a global basis. The CV SKG Expert will be influencing the shaping of the organisation by providing strategic direction and applying a full understanding of global issues related to drug/biological-induced CV toxicity. The role impacts the entire function and the broader AZ organization.

Responsible for managing global or regional therapeutic/ research projects or acting as an expert involved in the design conduct monitoring data interpretation and reporting of individual clinical trials. Ensures projects adhere to Good Clinical Practice and regulatory requirements. Will be responsible for overseeing development of the functional strategy or act as renowned expert in own field.

Responsible:

The Cardiologist at the AZ ECG Centre Role:

Provides cardiology scientific author and reviewer contributions to development of clinical study documents (Study

Synopses Clinical Study Protocols Statistical Analysis Plans and outputs and Clinical Study Reports)

Delivers digital ECG data review and interpretation in clinical studies where the AZ ECG Centre delivers ECG Corelab

services and provides second opinion on the observed ECG/Arrhythmia/Vital Signs and other CV findings of clinical or

drug safety concern to Project Teams/ Investigators when requested.

Supervises and mentors ECG Scientific Advisors

Provides expert contribution to the development testing and validation of new methodologies for ECG and Holter

signals analysis.

Provides expert contribution to the development testing and validation of new methodologies for blood pressure

recording

Provides expert contribution on applicability of new CV devices connected devices and wearable CV digital devices in

AZ clinical trials.

Provides expert advice on the choice and use of appropriate CV Imaging techniques other laboratory techniques and

safety cardiac biomarkers to optimize CV safety and to prevent CV toxicity in clinical trials.

The Cardiovascular Safety Knowledge Group Expert Role:

Acts as an expert involved in the design conduct monitoring data interpretation and reporting of potential clinical

safety signals related to CV toxicity which arise during the conduct of clinical trials.

Manages global research projects for state-of-the-art detection management and mitigation of clinical safety signals

related to CV toxicities

Ensures the research projects related to drug-induced CV toxicity adhere to Good Clinical Practice and regulatory

requirements.

Acts as renowned expert in the cardiovascular safety field to provide expert scientific and medical input to Global

Patient Safety activities with special focus on cross-project and cross-TA activities of a scientific nature

Leads and endorses the development of scientific methods applied to a wide range of safety data related to drug-

induced drug/biological- induced CV toxicity

Promotes safety sciences and clinical safety across projects and therapeutic areas

Provides support as needed for discussions with internal governance and international regulatory bodies

Contributes to improved understanding and prevention of drug/biological-induced CV toxicity issues across functions

within the company and across Pharmaceutical Companies and Regulatory Authorities.

Contributes to the implementation of the Global Patient Safety strategy and to the successful implementation of the global working model for the Clinical Safety Section. Leads drug/biological-induced CV toxicity biomarker development projects and contributes to the CV preclinical strategies set-up by the preclinical CV toxicity strategy Lead.

Essential:

Medical practitioner (medical degree) with at least 5 years drug development experience.

Specialty training and board certification in the field of expertise

Recognized by peers for therapeutic area expertise and commercial/safety understanding

Regulatory Agency interactions experience (authoring briefing documents / regulatory responses / label discussions)

Leading cross-functional teams

Broad knowledge of drug development and global regulatory requirements with regards to cardiovascular-specific safety evaluation safety reporting and risk management strategies

Influencing skills excellent verbal and written communication skills

Capable of conceptual thinking and strategic vision with respect to cardiovascular toxicity

Ability to identify and mitigate against cardiovascular toxicity risks.

Ability to establish causality in cases of CV injury.

Ability to define best practices in CV safety.

Desirable:

At least 2 years of patient safety experience

Experience in setting up internal and external collaborations (e.g. safety consortia) to promote organ safety

Academic / research experience in kidney injury

Demonstrated experience in adopting new technology (biomarkers etc.)

Strategic thinking and influencing with respect to CV safety

Demonstrated capability to lead implementation of new technology and/or working routines within a complex organization.

Strong team-working skills and an ability to work collaboratively in a global pharmaceutical environment

Date Posted

02-Feb-2026

Closing Date

01-Mar-2026

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.

Required Experience:

Exec