Principal I, Technical Program Management

Principal I Technical Program Management

Role Summary
PacBio is seeking a Principal I Technical Program Management within Systems Engineering to support execution across a portfolio of R&D programs and cross-functional initiatives spanning Chemistry Software Hardware Cells Consumables and System efforts.
This role drives portfolio planning and operating cadence maintains an integrated view of priorities and dependencies and enables clear data-driven tradeoff decisions on scope timing and resource allocation to deliver predictable outcomes.

Key Responsibilities

Portfolio Leadership & Prioritization
Provide an integrated view across assigned cross-functional initiatives: milestones dependencies risks and status to support decision-making.
Partner with functional leaders to set and refresh priorities based on strategy technical readiness risk and capacity constraints.
Lead tradeoff discussions and recommendations across scope schedule and resources; drive alignment on what moves forward now vs. later.
Establish lightweight portfolio governance: intake prioritization quarterly planning change control and escalation paths.

Resource & Capacity Management
Partner with other TPMs and functional leaders to maintain demand/capacity visibility and identify bottlenecks early.
Drive cross-functional alignment on resource conflicts and timing tradeoffs escalating as needed.

Cross-Functional Program Execution
For major initiatives develop and maintain integrated plans (milestones dependencies deliverables acceptance criteria).
Drive cross-team coordination across Chemistry SW HW Cells Consumables and System teams to ensure system integration readiness.
Participate in core team meetings cross-functional reviews & executive readouts.

Risk Issue and Change Management
Maintain portfolio-level RAID and decision logs; ensure timely mitigations and escalation when needed.
Manage change impacts from technical discoveries scope shifts slips and resource changes; keep leadership aligned on consequences.

Stakeholder Communication & Reporting
Provide crisp reporting: dashboards milestone health risk summaries dependency maps and resource tradeoff recommendations.
Translate across disciplines to ensure shared understanding of constraints and integrated timelines.

Required Qualifications
Typically requires a minimum of 11-14 years of related experience with a Bachelors degree; or a minimum of 9-12 years of related experience with a Masters degree; or a minimum of 8-11 years of related experience with a PhD.
10 years of technical program management or equivalent experience.
Proven success leading a portfolio of cross-functional technical initiatives including prioritization and resource allocation under constraints.
Experience coordinating complex R&D work across hardware and software disciplines; Fluent in technical discussions and able to translate requirements and constraints across teams.
Demonstrated strength in portfolio planning/governance dependency management risk management and executive-ready communication.
Strong ability to influence without authority and drive accountability across senior stakeholders.
Experience in biotech medical devices or other regulated domain in life sciences.
Excellent interpersonal written and verbal communication skills.

Preferred Qualifications
Experience in life sciences instrumentation sequencing technologies semiconductors/chips robotics or regulated product development.
Familiarity with system-level development lifecycle (requirements integration verification/validation transfer).
Working knowledge of design controls and change control.

Candidates must have current authorization to work in the United States without the need for present or future sponsorship.

Non-Field Based Employees are required to be onsite Monday-Thursday (Friday work from home). Depending on the role some employees may be required to be 100% onsite.

You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties.

All listed tasks and responsibilities are deemed as essential functions to this position; however business conditions may require reasonable accommodations for additional tasks and responsibilities.

All qualified applicants will receive consideration for employment without regard to race sex color religion national origin protected veteran status or on the basis of disability gender identity and sexual orientation.

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All qualified applicants will receive consideration for employment without regard to race sex color religion national origin protected veteran status or on the basis of disability gender identity and sexual orientation.

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