Postdoctoral Fellow – Statistical methods on Dose Optimization in Oncology and Informing Late Phase

Postdoctoral Fellow Statistical methods on Dose Optimization in Oncology and Informing Late Phase

Location: Gaithersburg MD (USA)

Competitive Salary Bonus & Benefits Package

Introduction

We are currently looking for talented scientists to join our innovative academic-style Postdoc Program. From our center in Gaithersburg MD youll be in a global pharmaceutical environment contributing to live projects right from the start. Youll take part in a comprehensive training program including a focus on drug discovery and development given access to our existing Postdoctoral research and encouraged to pursue your own independent research in cutting edge laboratories. Its a newly expanding program spanning a range of therapeutic areas across a wide range of disciplines.

Whats more youll have the support of a leading academic advisor Dr. Yong Zang from Indiana University wholl provide you with the guidance and knowledge you need to develop your career. This is an exciting area that hasnt been explored to its full potential making this an opportunity to make a real difference to the future of medical science.

About Oncology Biometrics

Our Oncology Biometrics department is an integral part of the Oncology R&D organization. We drive excellent design in order to generate the appropriate data needed for quality decision making. The goal of Oncology Biometrics is to deliver value to the pipeline by excellence in delivery improved decision making and engaging and shaping the external environment whilst accessing and implementing innovative solutions.

You will sit within our Statistical Innovation group in Oncology Biometrics (OBM) department which is a methodological hub for statistical design and analysis of clinical trials. Working as part of Statistical Innovation you will be able to access technology at the forefront of science in an innovative environment where you will have the scope to develop creative statistical ideas and approaches and to apply them in your work.

About the Opportunity

Optimizing doses and biomarkers in early-phase trials to inform Phase III dose and population decisions is a priority at AstraZeneca. Statistical approaches to address dose optimization and consideration of the population are needed. Adaptive design Bayesian analysis statistical modelling and utility-based approaches will be an important component of this project. The overall objective for this position will be to identify trial design and analysis methods to advance the goals of dose optimization and integrate biomarker optimization.

The postdoc will join our collaborative and supportive DOWGS (Dose Optimization Working Group Statistical Innovation) group and SIMBA (Statistical Innovation Meets BiomArker discovery) group supervised by Dr. Gina DAngelo. They will also have close interactions with scientists of various backgrounds including statisticians data scientists clinicians regulatory and precision medicine.

Project Focus

The project will begin with a critical evaluation of existing approaches. Subsequent methodological work will focus on dose-optimization approaches evaluating utility-based approaches missing data approaches pooling multiple sources of data including data from other trials jointly optimizing the dose and biomarker and trial design. The postdoc will be responsible for writing scientific papers presenting talks and supporting the scientific development of statistical methodology at AstraZeneca.

Our Postdoc program is aimed at individuals with a strong publication record who are either:

• Within 5-years of obtaining their doctoral degree (PhD DVM or MD) - PhD already awarded or
• Students soon to obtain doctoral degrees (the PhD must be awarded within 6 months of joining AstraZeneca).

Essential Education and Experience:

• PhD in Statistics or related field (or near completion of PhD)
• 0-4 years scientific working experience
• Good knowledge of the statistical software R.
• The ability to work collaboratively to solve statistical problems.
• Demonstrated effectiveness in presenting scientific work.
• Ability to communicate statistical ideas to scientists who are not statisticians.
• Data analysis and Computer coding
• Evaluating and developing new statistical methodologies
• Collaborate with scientists (statisticians and non-statisticians)
• Outstanding communication skills both written and oral

Desirable Qualifications:

• Contributed to scientific papers and/or presented at scientific conferences
• Experience in statistical topics that are closely related to the project such as dose-optimization biomarkers statistical modelling adaptive design Bayesian methods
• Proven ability to steer the direction of scientific work
• Fundamental knowledge of biomedical research and drug development

About our PostDoc Program

Bring your expertise apply your knowledge follow the science and make a difference. AstraZenecas Postdoc Program is for self-motivated individuals looking to deliver exciting projects in an encouraging engaging and innovative environment. Youll work with multidisciplinary scientific teams from a diverse set of backgrounds and a world-class academic mentor specifically aligned to your project. Our postdocs are respected as specialists encouraged to speak up and supported to share their research at conferences publish papers achieve their goals.

Make a more meaningful impact in your career with greater ownership and accountability to make a contribution whilst making a difference to the lives of our patients!

This is a 3-year program.

Compensation for this role based on years of experience after obtaining PhD is a minimum of $108500 up to a maximum of $123694 short-term incentive. Some relocation supplements depend on distance and location at the employers discretion.

About AstraZeneca

AstraZeneca is a global science-led patient-centered biopharmaceutical company focusing on discovering developing and commercializing prescription medicines for some of the worlds most serious diseases. But were more than a global leading pharmaceutical company. At AstraZeneca were dedicated to being a Great Place to Work and empowering employees to push the boundaries of science and fuel their entrepreneurial spirit.

Where can I find out more

AZs Postdoc Program: at AstraZeneca: is what were made of: Posted

Closing Date

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and furtherance of that mission we welcome and consider applications from all qualified candidates regardless of their protected characteristics. If you have a disability or special need that requires accommodation please complete the corresponding section in the application form.