Flow Cytomery Unit Manager

Bristol - UK

Monthly Salary: Not Disclosed

Posted on: Yesterday

Vacancies: 1 Vacancy

Job Summary

For 75years Charles River employees have worked together to assist in the discovery development and safe manufacture of new drug therapies. When you join our family you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences finance IT sales or another area your skills will play an important role in the work we return well help you build a career that you can feel passionate about.

Have you become the goto expert for advanced flow cytometry and are you ready to lead evolve and scale sitewide technical capability

Do you want to combine handson technical leadership with strategic influence driving innovation and excellence in advanced flow cytometry at a Discovery and Safety level

We are recruiting for a Technical Leader in Flow Cytometry to shape scientific direction drive innovation and strengthen Discovery and Safety capabilities at our Portishead site.

What Youll Be Doing

Scientific / Technical Responsibilities

Lead the operation development and strategic growth of the Flow Cytometry Facility ensuring provision of highquality highthroughput cytometry services across Discovery divisions.

Design optimise and validate complex multiparametric flow cytometry panels (analytical and sorting) including development of novel assay formats to meet emerging scientific needs.

Oversee instrument performance across all flow cytometers and sorters ensuring daily QC troubleshooting maintenance calibration and coordination of engineer support when required.

Drive the evaluation implementation and integration of new flow cytometry technologies (e.g. spectral cytometry highparameter analysis imaging flow cytometry) to expand Biotherapeutics Division capabilities.

Provide expert support to project teams by advising on experimental strategies marker selection panel design gating approaches and data interpretation.

Serve as the technical lead for flow cytometry in internal and external collaborations including technology vendors and client scientific teams.

Establish and enforce robust documentation standards for experimental workflows instrument logs QC data and facilitywide SOPs.

Lead the procurement of new cytometry instrumentation and software including preparation of technical justifications for CAPEX and operational budget planning.

Facility Management & Leadership

Develop and deliver training programs for users at all experience levels ensuring safe and competent operation of analysers and sorters.

Mentor scientific staff and junior cytometry specialists modelling best practice and supporting technical skill progression.

Coordinate work for other team members including supervision of facility staff where applicable.

Champion continuous improvement within the facility by refining workflows implementing automation or digital solutions and reducing variability in experimental procedures.

Maintain facility compliance with all CRL health safety and biosafety requirements proactively identifying risks and implementing corrective actions.

Data Software & IT Systems

Serve as an expert user of data analysis platforms (e.g. FlowJo) and support teams in applying advanced analysis strategies.

Oversee digital data management practices for the facility ensuring secure storage traceability and retrieval of cytometry datasets.

Identify and implement software upgrades or new analysis platforms that enhance scientific insight or operational efficiency.

Collaboration & Communication

Communicate scientific findings facility updates troubleshooting insights and strategy proposals clearly to both internal and crosssite stakeholders.

Represent the Flow Cytometry Facility and discipline at internal leadership forums crosssite technical groups and capability development discussions.

Provide highlevel technical input into business development activities including client interactions proposal development and scientific scoping.

Profile and Requirements

Essential

MSc in a relevant scientific discipline or equivalent experience.

Extensive handson experience in flow cytometry within a research or drug discovery environment.

Proven expertise in designing optimising and analysing complex multicolour flow cytometry panels including use of analysers and cell sorters.

Strong experience providing technical leadership mentoring and training scientific teams.

Deep knowledge of advanced flow cytometry including QC troubleshooting data analysis and interpretation.

Experience supporting discovery drug pipeline programmes including immunological assay development.

Excellent communication and influencing skills able to explain complex concepts clearly.

Ability to work onsite in Portishead with willingness to represent Charles River externally when required.

Desirable

PhD in a relevant discipline.

Experience leading a flow cytometry facility or crosssite technical capability.

Experience with BD flow cytometers and / or Cytek Aurora platforms.

Involvement in clientfacing projects collaborations or scientific conferences.

What We Offer You

Meaningful scientific impact contribute to research that supports the development of lifechanging therapies.

Career development & mobility strong opportunities for progression learning and crosssite or crossdiscipline growth within a global organisation.

Collaborative scienceled culture work alongside highly skilled scientists in multidisciplinary teams with access to advanced platforms and technologies.

Investment in learning continuous professional development training and access to new scientific tools and capabilities.

Competitive reward & benefits including salary pension and a comprehensive benefits package.

Worklife balance & wellbeing a culture that supports flexibility wellbeing and longterm career sustainability.

Stability with innovation backed by a global organisation while still driving innovation at site and programme level.

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies with over 350patents and 80preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists our comprehensive integrated portfolio employs the latest technology and platforms to provide chemistry biology and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused collaborative approach creates true partnerships that anticipate challenges overcome obstacles and move us forward together on the journey of getting new drugs to market.

About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services both Good Laboratory Practice (GLP) and non-GLP to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model which reduces their costs enhances their productivity and effectiveness to increase speed to market.

With over 20000 employees within 110 facilities in over 20 countries around the globe we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our clients unique challenges. Our client base includes global pharmaceutical companies biotechnology companies government agencies and hospitals and academic institutions around the world.

At Charles River we are passionate about our role in improving the quality of peoples lives. Our mission our excellent science and our strong sense of purpose guide us in all that we do and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly worked on 80% of the drugs approved by the U.S. Food and Drug Administration (FDA) in the past five years.

At Charles River Laboratories we recognize and recruit all talent. We are a company committed to fostering a sense of belonging and work daily in this direction.

Required Experience:

Manager