Vice President, Clinical Operations

Cytokineticsis a specialty cardiovascular biopharmaceutical company building on its over 25 years of pioneering scientific innovations in muscle biology and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction.

At Cytokinetics each team member plays an integral part in advancing our mission to improve the lives of patients. We are seeking tenacious compassionate and collaborative individuals who are driven to make a positive impact.

The Vice President Clinical Operations provides strategic and operational leadership for the execution of Cytokinetics global clinical development programs. Reporting to the SVP Development Operations this role is accountable for delivering high-quality compliant and efficient clinical trials that advance Cytokinetics mission to improve outcomes for patients with serious muscle-related diseases.

Consistent with Cytokinetics leadership expectations the VP Clinical Operations leads with a strong sense of ownership scientific rigor integrity and collaboration while maintaining an unwavering focus on patients data quality and regulatory excellence. This role is based on-site in South San Francisco and is a key leadership presence within the Development organization.

Key Responsibilities

Enterprise and Patient-Focused Leadership

• Lead clinical operations with apatient-first mindset ensuring participant safety ethical conduct and data integrity are central to all decisions.

• Act as an enterprise leader within Development Operations balancing asset-level priorities with portfolio-level needs.

• Model accountability transparency and integrity in all interactions consistent with Cytokinetics leadership expectations.

Scientific and Operational Excellence

• A valued strategic partner in the development of clinical program strategy

• Translate clinical development objectives into executable operational strategies that reflect Cytokinetics commitment to rigorous science and high-quality data.

• Provide operational leadership for Phase 13 and post-approval studies including large global cardiovascular trials.

• Ensure trials are conducted in full compliance with ICH-GCP FDA EMA and other applicable global regulations.

• Provide strategic direction and long-range planning enabling Clinical Operations to be at the forefront of performance.

Ownership and Results Orientation

• Own delivery of clinical trial milestones timelines and budgets across the development portfolio.

• Proactively identify operational risks and implement mitigation strategies escalating issues with clarity and solutions.

• Establish and monitor performance metrics that drive accountability and continuous improvement.

Collaborative One-Team Leadership

• Partner closelywithseniorcross-functionalpeerswithinClinicalResearch Biometrics Regulatory Affairs QualityAssurance (QA) Medical Affairs CMCOperational Excellence Clinical Compliance and Training (CCaT)and other functions to ensure alignment andintegrated execution.

• Foster strong cross-functional decision-making grounded in mutual respect scientific debate and shared goals.

• Represent Clinical Operations effectively in governance forums and executive discussions.

• Establish a consistent approach in clinical trials strategy and practices across all programs

Vendor and Partner Stewardship

• Lead Clinical Operations CRO and vendor strategy with a focus on partnership performance and accountability.

• Ensure external partners operate to Cytokinetics standards for quality compliance and ethical conduct.

• Serve as Clinical Operations executive lead on strategic and partner joint-development activities

• Resolve escalated issues in a decisive solution-oriented manner.

People Leadership and Talent Development

• Build lead and develop a high-performing Clinical Operations organization aligned with Cytokinetics leadership behaviors

• Create an inclusive collaborative environment that drives engagement and performance; provides opportunities for growth and development and proactively removes barriers

• Actively mentor senior leaders and develop succession plans to support organizational sustainability.

Quality and Inspection Readiness

• Ensure continuous inspection readiness and strong collaboration with CCaTandQA.

• Lead responses to audits and inspections with rigor transparency and corrective action discipline.

• Reinforce a culture where quality is owned by the organization.

• Support the development and implementation of best practices SOPs standards work instructions and policies for Clinical Operations.

Qualifications

Education

• Bachelors degree required; advanced degree (MS MPH PharmD PhD) preferred.

Experience

• 18 yearsof progressive clinical operations experience in biotechnology or pharmaceuticals.

• Proven leadership with all phases of clinical trials; cardiovascular or rare disease experience strongly preferred.

• Demonstrated success leading teams in a late-stage science-driven biotech environment.

• Extensive experience managing CROs and global vendors.

• Drug development experience in being a strategic partner for program strategy.

Capabilities Aligned to Leadership Expectations

• Demonstrated ability tolead with integrity accountability and ownership.

• Strong scientific judgment paired with operational discipline.

• Ability to collaborate effectively in an onsite fast-moving cross-functional environment.

• Clear influential communicator at the executive and Board-facing level.

Work Environment and Travel

• This role ison-siteat Cytokinetics headquarters inSouth San Francisco CA.

• Domestic and international travel expected (approximately15%).

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Pay Range:

Our employees come from different backgrounds and we celebrate those differences. We are looking for the best candidates for our open roles but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team we would love to hear from you.

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Our passion is anchored in robust scientific thinking grounded in integrity and critical thinking. We keep the patient front and center in all we do all actions and decisions are in service of the patient and their caregivers. We champion integrity ethics doing the right thing and being our best selves.

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Cytokinetics is an Equal Opportunity Employer