Title: Post-doctoral Fellow
Salary: Commensurate with experience
Department: Hematology and Medical Oncology
Physical work location: (must be proper street address) 1468 Madison Avenue New York NY
Name PI or Supervisor: (include phone and email) Hanna Irie MD PhD
Administrative Contact: (phone and email) Randa Hazar
Details of Research Project:
The researcher will be engaged in translational cancerresearch projects focused on regulators of growth survival and drug resistance of breast and other cancers as well as their microenvironment especially immune effectors. The researcher will use a broad range of approaches (genetic cell biologicalandinvivomodeling) tounderstandhowbreastcancersparticularlytriplenegativebreastcancersresist chemotherapy treatments and metastasize. The projects also examine novel mechanisms that contribute to the -derivedxenograftmodels of breast cancer and organoid cultures to screen and validate novel therapeutic strategies in collaboration with and other cancers to chemotherapy/targeted therapies. The researcher will be expected to design and conduct experimentsberesponsibleforaccuraterecordkeepingandcontributetooverallmaintenanceofthelaboratory.
Background in cancer cell biology/models genetics molecular biology biochemistry or immunology required. Experiencewithmousetumormodelsandrelatedprocedures(handlingtumorcellinjectionflowcytometrymouse surgical procedures IVIS imaging) strongly preferred
Ph.D or MD/PhDrequired with at least two years of laboratory experience.
Technical Duties: (include any protocols)
-Cell culture
-Western Blot
-Cell viability assays
-qPCR
-DNA preparation (bacterial transformation DNA extraction transfection)
-Lentivirus production
-Mouse handling-tumor cell injections mouse surgeries IVIS imaging
-Flow cytometry
-Organoid development and culture
-Microscopy
-Lab record keeping
-Contribute to laboratory maintenance
Educational and other Requirements for the position:
Minimum B.A./B.S. required with at least two years of laboratory experience. Candidates with M.A./M.S. or other advanced degrees will also be considered.
Experience Required: At least two years of wet bench laboratory experience
Goals/Outcomes of the Research Project:
The goals are to develop and validate novel therapeutics targeting novel oncogenes in breast cancer models.
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