Senior Scientist I, Process Engineering

R&D Process Engineering a part of AbbVie R&Ds Synthetic Molecule CMC Development organization is responsible for designing and developing scalable processes to make small molecule drug substances and drug products antibody drug conjugates (ADCs) and peptides throughout pre-clinical and clinical development stages. R&D Process Engineering also partners with Biologics CMC Development and Aesthetics R&D functions to provide active engineering support to enable robust process scale-up and manufacturing of biologics drug substances and drug products including toxins and cosmetic active ingredients (CAIs). We contribute to the development of innovative engineering technologies and create valuable intellectual property through the composition of matter chemical processes and technologies resulting in cost-effective commercial manufacturing processes. We support the development of the supply chain for pipeline molecules and help prepare and defend CMC regulatory content.

Chemical/Bio Engineers support pipeline projects through all phases of development. Early in development engineers focus on ensuring that the process can be run safely identifying and addressing scale-up issues enabling processes that can be scaled-up the later stages of development engineers optimize the drug substance and drug product processes and lead manufacturing campaigns.

Role Overview

The successful candidate will play a key role spanning multiple R&D Process Engineering functions including the Crystalline Drug Substance and Drug Product Group (CrySP) and the Center for Reaction Engineering (CRE). The core deliverable of Process Engineering is to develop robust processes to manufacture small molecule Active Pharmaceutical Ingredients (API) ADCs toxins CAIs and drug products utilizing strong engineering fundamentals. The ideal candidate will have a demonstrated background in crystallization fundamentals and crystallization process development. Further the candidate will have demonstrated expertise in solving challenges in reactions relevant to manufacture of drug substance and drug product pharmaceutical and aesthetic products.

R&D Process Engineering leads the development of commercial-ready isolation and purification strategies for both small and large molecule compounds.  The ideal candidate will have a passion for hands-on laboratory process development and a proven track record in research and development.  The candidate is expected to lead the identification and development of novel approaches and technologies to enhance process development efficiency and commercialization. The candidate must exhibit a collaborative nature in identifying process challenges on a wide range of projects and participate in cross-functional teams to deliver against specific project needs.

Key Responsibilities:

• Develop robust scale up and manufacturing processes supporting small and/or large molecule assets through all phases of development. 
• Perform laboratory experiments and process modeling to support process understanding and optimization.
• Address challenging problems with separations and/or isolations using expertise in thermodynamics crystallization fundamentals transport phenomena and mathematical modeling. 
• Author and/or review technical documents summarizing process development efforts.
• Exhibit a collaborative nature in identifying process challenges on a wide range of projects and communicate findings and recommendations effectively by multi-disciplinary interactions with organic chemists analytical chemists process development engineers pilot plant engineers drug product development scientists program managers and regulatory affairs specialists.
• Exhibit capabilities to prototype innovative solutions to laboratory development problems.
• Author publications and present at scientific conferences. 

Qualifications :

• BS MS or PhD in Chemical/Bio Engineering or a related field and 10 (BS) 8 (MS) or 0 (PhD) years of relevant industrial experience.
• Job level will be commensurate with academic and/or industrial work experience.
• Candidates are expected to have a strong background in chemical engineering and the proven ability to demonstrate their skills in this field.
• The candidate is expected to demonstrate the ability to learn understand and master new experimental techniques.
• The candidate is required to possess effective oral and written communication skills and be a strong team player.
• Prior crystallization isolation or purification experience.

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time ofthis posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic locationand we may ultimately pay more or less than the posted range. This range may be modified in the future. 

• We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to participate in our short-term incentive programs. 

Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of anybonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys soleand absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

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Work :

No

Employment Type :

Full-time