Job Title: Technical Lead (HPC Infrastructure) - SCP
Location: Cambridge
Salary: Competitive
Introduction to role:
Are you ready to lead high-performance computing infrastructure that accelerates discovery and brings life-changing medicines to patients faster This is your opportunity to set the direction for a mission-critical platform that underpins data science computational biology and AI/ML workloads across the enterprise.
You will steer a modern HPC environment spanning on-premises and cloud enabling scientists to run at scale and speed while maintaining reliability and cost efficiency. Do you thrive at the intersection of engineering rigor and scientific impact where your decisions unlock faster insights and smarter experimentation
In this hands-on leadership role you will be empowered to take ownership challenge the status quo and orchestrate new possibilitiespartnering closely with researchers pushing boundaries in hackathons and ensuring our platform evolves with the demands of cutting-edge science.
Accountabilities:
Platform Roadmap: Define and own the strategic roadmap for the HPC infrastructure aligning capacity architecture and capabilities to scientific priorities and business outcomes.
Operational Excellence: Drive continuous improvement of platform stability efficiency and performance; set clear metrics and ensure reliability for large-scale workloads and time-critical studies.
Hybrid Delivery: Lead delivery across on-premises and cloud environments optimizing for speed scalability and cost while ensuring seamless user experience.
Scientific Partnership: Work with scientific users to understand their needs and translate them into robust solutions enabling faster models simulations and analyses.
Technology Foresight: Scan the horizon to identify emerging technologies that keep the platform innovative and competitive and guide timely adoption.
Backlog Leadership: Prioritize the teams work based on scientific impact balancing quick wins with longer-term investments to maximize value.
People Development: Mentor and coach engineers build capabilities and foster a high-performance collaborative engineering culture.
Incident Leadership: Investigate and resolve complex operational incidents lead root-cause analysis and implement preventative improvements that strengthen the platform.
Essential Skills/Experience:
Defining the roadmap for the platforms HPC infrastructure
Drive continuous improvement of the stability and efficiency of the platform
Ensuring delivery of team objectives both on-premises and in the cloud
Working with scientific users to understand their needs and develop solutions
Horizon scanning identifying the future technologies needed to stay innovative
Prioritising the work backlog for the team according to scientific needs
Mentoring and coaching engineers
Investigating and resolving complex operational incidents
Desirable Skills/Experience:
Experience with HPC schedulers and workload managers (e.g. Slurm PBS Grid Engine) and job orchestration at scale
Hands-on knowledge of cloud-based HPC services and architectures (e.g. Azure AWS GCP) hybrid networking and cost optimization
Containerization and orchestration for scientific workloads (e.g. Docker Singularity Kubernetes)
Infrastructure as Code and automation (e.g. Terraform Ansible CI/CD) plus strong scripting skills in Python and Bash
Performance tuning and profiling of compute and storage including GPUs accelerators and parallel filesystems (e.g. Lustre Spectrum Scale)
Workflow management tools (e.g. Nextflow Snakemake) and data pipelines supporting AI/ML and bioinformatics
Robust approach to reliability engineering observability and security/compliance for sensitive research data
Proven stakeholder engagement across research engineering and product teams with the ability to balance speed quality and sustainability
Why AstraZeneca:
Here technology and science move together with purpose. You will join a community of entrepreneurial self-starters who experiment boldlythrough hackathons collaborations with leading academics and partnerships across the enterpriseto deliver digital capabilities that scale fast and unlock the potential of research. We value kindness alongside ambition expect high standards and back them with investment so your contribution directly fuels our progress toward a truly data-led organization that changes lives.
So whats next
Complete your application before the below closing date.
We welcome your application no later than 15th February 2026
Where can I find out more
Follow AstraZeneca on LinkedIn AstraZeneca on Facebook AstraZeneca on Instagram Posted
03-Feb-2026Closing Date
15-Feb-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, ... View more