Research Lab Manager, Infectious Disease, Dr. Pritha Sen Lab

Site: The Brigham and Womens Hospital Inc.

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Job Summary

The Sen Laboratory located in the Longwood Medical Area at Brigham and Womens Hospital (BWH) is looking for a Research Laboratory Manager who has experience and/or expertise in performing single-cell and nuclei RNA sequencing wet bench/experimental protocols in per diem role to support several ongoing projects in the lab. Our research lab focuses on translational human immunology studies of viral immunity and immunopathogenesis in the immunocompromised host. Knowledge gained from these studies will help to guide the design of more effective eradication strategies and treatments against various infectious pathogens.

The applicant must have a minimum of 3 years of experience in an academic and/or laboratory research setting AND have at least 1 year of experience in executing emulsion-based single-cell/nuclei library generation and next-generation sequencing workflows and be highly organized meticulous and rigorous in the implementation of wet bench experimental protocols. The applicant will work independently but be trained in best practices and supervised closely by the Principal Investigator; perform duties in accordance with established hospital policies and procedures and conduct a variety of experiments with established methodologies; participate in the design and modification of research protocols; and contribute to figure generation and methods and results writing for abstracts research reports and manuscripts. The applicant will coordinate lab activities as it relates to these specific experiments assist in general lab management issues and undertake quality assurance programs. A minimum 1-year commitment is required.

PRINCIPAL DUTIES AND RESPONSIBILITIES:

1. Supervises and/or implements the wet-bench single-cell and sequencing operations of the lab under the supervision of the Principal Investigator
2. Oversees supply inventory as it relates to high-dimensional immunophenotyping and sequencing performed in the lab under supervision of the Principal Investigator.
3. Processing of clinical human blood (i.e. Ficoll for PBMC centrifugation for plasma and serum isolation) and tissues specimens (i.e. hot and cold digestion and mechanical separation of human tissue biopsies) for single-cell and sequencing workflows from patients with bacterial viral and fungal infections under supervision of Principal Investigator.
4. Participates in the design and modification of single-cell sequencing and immunophenotyping research protocols.
5. Participates in the maintenance of specialized equipment used for single-cell sequencing and immunophenotyping experimental workflows.
6. Develops research methodologies within parameters of experimental protocols and research objectives.
7. With appropriate support willing to performs data analysis using advanced statistical techniques.
8. Contribute to writing sections of research reports and manuscripts.
9. Responsible for the oversight and coordination of all lab activities including quality assurance.
10. Responsible for the oversight and coordination of all scheduling of all procedures.
11. Responsible for troubleshooting problems and instructing others in highly specialized techniques.
12. If entry-levels research staff is present responsible for supervising staff in the lab.
13. In collaboration with Principal Investigator participates in budget and grant development and preparation.
14. Records data summarizes and analyzes results using basic statistics.
15. Prepares laboratory reagents chemicals instruments and equipment.
16. Maintains supplies inventory in accordance with departmental procedures.
17. Attends lab meetings and discusses progress of work regularly with supervisor.
18. All other duties as assigned.

Education
Bachelors Degree Related Field of Study required. Specialized training in genomics and or immunology would be considered favorably.

Experience
Experience in an academic or laboratory research setting 3-5 years required

Minimum 1 year of experience performing single-cell/nuclei library generation and next-generation sequencing workflows


Knowledge Skills and Abilities

Ability to make independent decisions.

Aptitude for technical problem solving.

Ability to effectively supervise others.

Excellent Organizational skills.

Must possess strong budget and management skills.

Excellent judgement and ability to interpret information.

Interest in and comfort with working with human clinical specimens

Sound degree of computer literacy with basic programs (i.e. Microsoft Word Excel Powerpoint) with willingness to learn Adobe Illustrator reference managers (i.e. Zotero)

Ability to record and analyze data using basic statistics

Ability to perform a variety of routine tests and prioritize work

Outstanding interpersonal and communication skills

Ability to demonstrate highest levels of professionalism

Onsite

181 Longwood Avenue

0

Per Diem

Day (United States of America)

Pay Range

$37.95 - $61.99/Hourly

Grade

8

At Mass General Brigham we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive and any offer extended will take into account your skills relevant experience if applicable education certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however it does not encompass all elements contributing to your total compensation addition to competitive base pay we offer comprehensive benefits career advancement opportunities differentials premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply and our Talent Acquisition team will provide an overview of your potential compensation and benefits package.

2200 The Brigham and Womens Hospital Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religious creed national origin sex age gender identity disability sexual orientation military service genetic information and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973 the Vietnam Veterans Readjustment Act of 1974 and Title I of the Americans with Disabilities Act of 1990 applicants who require accommodation in the job application process may contact Human Resources at .

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