Organic Chemist Intern

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Internship in Synthetic Organic Chemistry Johnson & Johnson Spring House (Graduate Student)

Job Description: The Discovery Process Research (DPR) group of Johnson & Johnson Innovative Medicine is seeking an outstanding and motivated graduate student for a summer internship to be based in Spring House PA. This internship is designed for advanced PhD candidates (students who have completed at least their third year of graduate research) with prior training in synthetic organic chemistry and a strong interest in reaction discovery and optimization. This role will provide the intern with exposure to the Johnson and Johnson Innovative Medicine research engine at the intersection between Discovery and Process chemistry. Interns will gain real-life training in the skills and tools relevant to employment within the broader area of drug discovery. Beyond gaining industrial experience and networking the intern will contribute to the design and development of novel robust and scalable chemical transformations at the interface of small-molecule and peptide chemistry with an opportunity to present and publish their work.

The synthetic organic chemistry intern will:

• Design and execute exploratory experiments focused on reaction discovery and optimization

• Develop and evaluate synthetic routes for small molecules and peptide intermediates

• In the peptide space the intern will perform solid-phase peptide synthesis (SPPS) and explore on-resin and late-stage peptide functionalization including side-chain modification ligation or conjugation strategies

• In the small molecule space the intern will leverage high throughput experimentation techniques and catalysis to enable address key synthetic challenges

Synthesize purify and characterize relevant organic compounds

• Analyze products and intermediates using NMR LC-MS HPLC and related techniques

• Maintain thorough and compliant electronic laboratory notebook (ELN) documentation

• Prepare technical reports and present findings to cross-functional project teams

• Be exposed to various other functions within the drug discovery teams at Johnson & Johnson

• Participate in campus-wide activities across the Spring House summer intern community

• Be based in Spring House PA (suburban Philadelphia area)

Internship Details

• Duration: 1012 weeks

• Location: Spring House PA On-site

• Compensation: Competitive paid internship

• Start date: Flexible within program window

Required Qualifications

• Current enrollment in an accredited college/university pursuing a Ph.D. degree in a field related to organic chemistry

• Completion of at least three years of graduate research by the start of the internship with a strong foundation in synthetic organic chemistry

• Familiarity with standard analytical techniques (NMR MS HPLC) and synthetic workflows (work-ups isolations recrystallization column chromatography)

• Availability to work full-time during the internship period

• Strong organizational skills rigor and proven track record to balance multiple tasks

• Capacity to work independently as well as on a team

• Legal authorization to work in the United States and not require sponsorship for employment visa status (e.g. H1-B status) now or in the future

• Proficiency with Microsoft Office Word Excel and Power Point and have strong oral and written communication skills

• A minimum G.P.A. of 3.2 is strongly preferred

• Preferred Qualifications: Experience with any or all of the following synthetic paradigms: Solid Phase Peptide Synthesis Photochemistry Radical Chemistry Cross-Coupling Molecular Editing Total Synthesis

Equal Opportunity Statement: Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin or protected veteran status and will not be discriminated against on the basis of disability.

About the Discovery Process Research Group: Discovery Process Research at Johnson & Johnson sits at the critical interface between discovery and development. Our teams focus on enabling the rapid and reliable translation of novel chemical ideas into robust scalable synthetic processes that support the advancement of small-molecule and emerging modality programs including peptides antibody drug conjugates and oligonucleotides. Through reaction discovery route scouting and early process design we partner closely with medicinal chemistry analytical and development organizations to shape high-quality synthetic strategies from the earliest stages of a program. By combining deep expertise in synthetic organic and peptide chemistry with a strong emphasis on safety sustainability and manufacturability Discovery Process Research plays a key role in de-risking development accelerating timelines and delivering innovative medicines to patients worldwide.

About Johnson and Johnson and Our Mission: At Johnson & Johnson we believe good health is the foundation of vibrant lives thriving communities and forward progress. For more than 135 years we have been committed to advancing health through science innovation and a deep responsibility to patients around the world. Our organization focuses on developing transformational medicines across areas of significant unmet need including oncology immunology neuroscience infectious diseases and cardiovascular and metabolic disorders. Our teams bring together world-class scientists cutting-edge technologies and a strong culture of collaboration to help build a world where complex diseases are prevented treated and cured where treatments are smarter and less invasive and solutions are personal. Guided by Our Credo we are committed to conducting science with integrity advancing sustainability and fostering an inclusive environment where diverse perspectives drive innovation. Learn more at .

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