Principal Scientist, Process Chemistry
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Job Location:
Bothell, WA - USA
Monthly Salary:
$ 106000 - 171500
Posted on:
Yesterday
Vacancies:
1 Vacancy
Job Summary
ROLE SUMMARY
The Chemical Process and Analytical Development (CPAD) group in Bothell WA develops innovative and phaseappropriate synthetic routes and scalable chemical processes for novel small molecule targeted therapeutics. Our process chemists analytical scientists and chemical engineers collaborate to design robust safe and scalable chemistry that accelerates delivery of lifechanging therapeutics to patients.
As a Principal Scientist Process Chemistry you will serve as a key technical leader driving route scouting synthetic design process development and process characterization for our expanding portfolio. You will apply a strong foundation in modern synthetic organic chemistry and process development to build scalable innovative chemistry using stateoftheart technologies (HTE datarich experimentation continuous processing catalysis and predictive tools).
This role provides the opportunity to contribute through handson laboratory innovation while guiding strategy for early and latestage programs. You will mentor junior scientists influence crossfunctional project direction and represent process chemistry both internally and externally. You will also oversee execution of GMP production batches through technology transfer and campaign oversight.
ROLE RESPONSIBILITIES
- Design execute and interpret complex laboratory experiments aimed at route development process optimization and scaleup.
- Develop fitforpurpose processes for early and latestage programs ensuring safety robustness and scalability.
- Maintain rigorous laboratory records author patents and contribute to regulatory documents.
- Apply modern synthetic organic chemistry principles highthroughput experimentation mechanistic insight and datarich methods to accelerate development.
- Effectively communicate scientific strategy risks and solutions to project teams leadership and partner functions.
- Drive alignment to project timelines and portfolio strategy.
- Mentor junior staff and foster an inclusive scientifically rigorous and collaborative environment.
- Lead technology transfer and partner interactions to enable external development campaigns.
- Build strong stakeholder relationships across CPAD partner functions and project teams.
- Establish an external technical presence through publications and presentations.
BASIC QUALIFICATIONS
- PhD in Organic Chemistry with 4 years of industry experience in pharmaceutical process development including route design scaleup and GMP manufacturing; or a Masters degree with 10 years of relevant experience.
- Deep foundational understanding of synthetic organic chemistry reaction mechanisms process development and modern purification and analytical technologies.
- Demonstrated scientific impact via peerreviewed publications patents or conference presentations.
- Strong communication skills with ability to collaborate across scientific and engineering disciplines.
- Experience supporting development from preclinical through commercial stages.
- Experience in regulated pharmaceutical environments including GMP operations and authoring regulatory submissions.
- This is an onsite role (5 days/week).
- Submission of a research summary is required.
PREFERRED QUALIFICATIONS
- Experience developing druglinkers for ADCs PROTACS DACs or other targeted mixedmodality therapeutics.
- Experience mentoring and developing scientific staff.
- Experience with technology transfer and oversight of external development work.
Experience at innovator pharmaceutical companies strongly preferred.
Relocation support available
Work Location Assignment:On Premise
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race color religion sex sexual orientation age gender identity or gender expression national origin disability or veteran status. Pfizer also complies with all applicable national state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Required Experience:
Staff IC
Key Skills
- Machine Learning
- Python
- Data Science
- AI
- R
- Research Experience
- Sensors
- Drug Discovery
- Research & Development
- Natural Language Processing
- Data Analysis Skills
- Toxicology Experience
About Company
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