Principal Automation Scientist, In-Vitro Cell-based Screening and Mechanistic Profiling

This role isnt just about doing science its about reinventing how its done. As a subject matter expert you will lead initiatives to transform functional genomics and cell-based screening through automation and application of digital tools turning in vitro discovery into a smarter faster engine for breakthrough targets.

Your new role
As a Principal Automation Scientist in the In Vitro Discovery & Delivery (IDD) department you will define and deploy automation solutions and implement digital applications to accelerate data generation for in vitro functional genomics cell-based screening and large-scale mechanistic profiling. You will lead the design deployment and adoption of automated solutions tailored to complex in vitro cell-based workflows drive the choice and use of digital data applications and FAIR-aligned practices to scale throughput and ensure reproducibility for predictive target discovery across the IDD team based in Oxford. You will be instrumental in the teams ability to generate high-quality multi-modal datasets to improve the probability of success for novel targets and pipeline projects supporting more informed target nominations and de-risking portfolio decisions.

Your responsibilities will include:

• Strategic leadership: Define roadmaps and cross functional programs to transform in vitro target discovery through automation advanced data capture and multiomic integration.
• Automation & digital systems: Evaluate and implement scalable production ready solutions (robotics LIMS/ELN integrations data and imaging pipelines) to standardise experimental execution and data capture.
• FAIR data & tooling: Drive enterprise adoption of FAIR principles; set metadata data model and API standards and champion data provenance and accessibility.
• Advanced analysis & ML: Oversee statistical frameworks scalable analysis pipelines and fuel machine learning models with data for predictive target discovery; ensure validation explainability and deployment.
• Stakeholder engagement: Act as senior partner to Target Discovery Functional Genomics Technology Leaders Digital Biology Biology AI IDD US and Novo Nordisk automation engineers; build external collaborations with vendors CROs academia and industry partners.

Your new department
The In Vitro Discovery & Delivery (IDD) department based at Novo Nordisk Research Centre in Oxford is part of Novo Nordisk Global Research. As a state-of-the-art target discovery and validation research department it is responsible for identifying novel targets with mechanisms of action for diseases aligned with Novo Nordisk therapy area priorities. The centre uses innovative and unbiased in silico and in vitro human-centric collaborative approaches to identify new therapeutic opportunities for type 2 diabetes and obesity and their associated cardiometabolic co-morbidities including MASH and cardiovascular disease.

The department also drives productive collaborations with academia (particularly the University of Oxford) and biotechnology partners. The In Vitro Science team is part of a global organisation including a team based at the Novo Nordisk research centre in Boston. Together we work closely with our therapy area partners in the Global Research in Boston and Denmark to progress novel targets into Novo Nordisks early project pipeline.

Your skills & qualifications

• PhD or MSc in life sciences computational biology or related field.
• Extensive experience with medium to high throughput in vitro functional genomics and cell-based screening automation and digital workflows.
• Proven track record implementing FAIR data practices and deploying digital tools to support data analytics at scale ensuring future-proof data usage.
• Strong coding data engineering and automation platform experience; familiarity with cloud/ML pipelines desirable.
• Outstanding communication abilities and effective interpersonal collaboration skills.

Working at Novo Nordisk
Every day we seek the solutions that defeat serious chronic diseases. To do this we approach our work with determination constant curiosity and a commitment to finding better ways forward. For over 100 years this dedication has driven us to build a company focused on lasting change for long-term health. One where diverse thinking shared purpose and mutual respect come together to create extraordinary results. When you join us youre not just starting a job youre becoming part of a story that spans generations.

Deadline
13th February 2026.

Novo Nordisk is not your typical healthcare a modern world of quick fixes we focus on
solutions to defeat serious chronic diseases and promote long-term health. Our unordinary mindset is at the heart of everything we do. We seek out new ideas and put people first as we push the boundaries of science make healthcare more accessible and treat prevent and even cure diseases that affect millions of lives. Because it takes an unordinary approach to drive real lasting change in health.

We commit to an inclusive recruitment process and equality of opportunity for all our job applicants.

At Novo Nordisk were not chasing quick fixes were creating lasting change for long-term health. For over 100 years weve been driven by a single purpose: to defeat serious chronic diseases and help millions of people live healthier lives. This dedication fuels our constant curiosity and inspires us to push the boundaries of whats possible in healthcare. We embrace diverse perspectives seek out bold ideas and build partnerships rooted in shared purpose. Together were making healthcare more accessible treating and preventing diseases and pioneering solutions that create change spanning generations. When you join us you become part of something bigger a legacy of impact that reaches far beyond today.