Postdoctoral Fellow-MSH

New York City, NY - USA

Monthly Salary: Not Disclosed

Posted on: 17 hours ago

Vacancies: 1 Vacancy

Job Summary

Description

Details of Research Project:

How can neuroscience help us design and optimize treatments for devastating disorders of learning and memory Our lab directly addresses this challenge by leveraging our experimental platform to understand test and optimize therapeutic interventions for cognitive disorders. This project focuses on fornix deep brain stimulation (DBS-f)a promising treatment for Alzheimers disease currently in Phase III clinical trials. The mechanism of this therapy is not known. We will combine DBS-f with our large-scale recording platform to provide a mechanistic circuit-level explanation for its effects with the long-term goal of optimizing its clinical application.

Technical Duties: (include any protocols)

You will be a core driver of our labs scientific mission leveraging our custom-built research platform to answer fundamental questions about how the brain transforms experience into memory. Beyond the bench you will have the unique opportunity to bridge the gap between basic research and clinical application through our established network. Your responsibilities will include:

Leading complex experiments using large-scale Neuropixels recordings and patterned microstimulation (DBS) in behaving primates navigating immersive virtual reality environments.

Collaborating directly with world-renowned clinicians and experts in DBS to translate circuit-level findings into frameworks for understanding and treating Alzheimers disease and related dementias.

Investigating the circuit-level mechanisms of emerging therapies specifically focusing on the effects of fornix DBS on neural computation.

Mentoring junior lab members and assisting in the development of our growing research team.

Presenting your findings at international conferences (e.g. Gordon Research Conference Society for Neuroscience) and preparing manuscripts for high-impact publications.

Responsibilities

Experience Required:

Laboratory experience working in behavioural neuroscience prefereably with nonhuman primates

Analysis of behavioural and neural datasets

Proficiency in coding (C# Arduino bash)

Goals/Outcomes of the Research Project:

Mechanistic Understanding: Elucidate the circuit-level mechanisms by which DBS-f alters neural representations in the hippocampus and prefrontal cortex to improve learning and memory.

Therapeutic Optimization: Establish a framework for predicting and explaining the variable efficacy of DBS treatments paving the way for optimized clinical protocols.

Career Advancement: Produce high-quality datasets leading to first-author publications in top-tier journals and support the fellows transition to an independent research career.

Technological Innovation: Advance the use of large-scale recording technologies (Neuropixels) combined with neuromodulation in awake behaving primates

Qualifications

Educational and other Requirements for the position:

A PhD in Neuroscience Biomedical Engineering Psychology Electrical Engineering or a related field.

Proficiency in coding (MATLAB or Python) for data acquisition and analysis.

A strong interest in bridging the gap between basic circuit mechanisms and translational applications.

DescriptionDetails of Research Project:How can neuroscience help us design and optimize treatments for devastating disorders of learning and memory Our lab directly addresses this challenge by leveraging our experimental platform to understand test and optimize therapeutic interventions for cognitiv...