Senior Scientist – Translational Genomics, Translational Medicine
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Posted on:
8 hours ago
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1 Vacancy
Job Summary
Job Title: Senior Scientist Translational GenomicsTranslational Medicine
Location: Cambridge UK
Introduction to the role:
We are seeking aSenior Scientistto join ourTranslational Genomicsteam(Cambridge U.K.)on afixed termbasis.The successful candidate would be joininga world classcentrefordiscoveryand development of innovative cancer medicines. Based at the heart of the Cambridge UK biomedical research community you will play a keyrole in thedelivery of datautilizingcutting edgegenomics techniques.You will deliver high qualitybiomarkerdata from human clinical samples andhave the opportunity toimpactanexciting andindustry-leading portfolio of programs frominceptionthrough tolife cycle management.
About the role:
TheTranslationalMedicineGenomics Labfocuses on theexploratoryanalysis of clinical samples using the best available solutions to maximize value for oncology projects.Our work includes the analysis of fixed and frozen tissues liquid biopsymaterial and single cell and spatial genomics.We provide support via a mix of in-house lab analyses external providers and collaborators. We generate data to help understand key cancer pathway alterations guide drug combinations provide disease linkage data to guideindicationselection and targeted patient populations andunderstandthe dynamics of responseandresistance to therapies.
This role willhavea strong focus on hands-on laboratory work.You willbe responsible fortheplanning designand execution ofhigh-quality experimental workanddocumenting interpretingand communicating results toappropriate stakeholdersand partners. You willbe able towork independently butalso asakey member ofour globalteamof genomics anddata scienceexperts.
Major Responsibilities and Accountabilities:
- Work with UK and Global genomics colleagues Project Managers andTranslationalMedicine Leads (TMLs)to understand thegenomic biomarker needsof clinical studies
- Plan prioritiseand execute work to deliver tobiomarkerplansexploiting the mostappropriate technologies/assaysto deliver high quality data on time and to budget
- Work with Translational ClinicalBiosamplescolleagues and CRO partners to access the right samples at the right time
- Lead from the bench to generate data in a modern genomics lab utilising Automation DNA/RNA extractionlibrary preparationNGSsingle celland other platforms
- Utilise a sample management system and other software and communication tools to track samplesmonitorprogress and record data
- Workwith team members and aligned production informatics and bioinformatics experts to support data analysis/QCinterpretationand communication back toTMLproject team and other stakeholders
- Contribute to maintenance and development ofour internal genomics capabilitiesand development & implementation of new genomic/epigenomic assays or related technologies
- Support colleagues to train in existing and new SOPs
- As required - conceptualize develop and execute evaluations ofmethodsplatforms and emerging technologieswhich mayaddressareas of unmet need forprogrammes
- Provide technical advice and genomic biomarker consultation to internal and external partners
- Record and communicate your data accuratelyclearlyand concisely
- Maintainappropriate documentation be compliant with all internal and external policies and legal requirementsaround use of clinical samples consent and privacy
Essential skills and experience:
Advanced degreein a relevant discipline(preferablyPhDor equivalent)andat least4 years post-doctoral experience (or equivalent)utilising advanced molecular biology techniques (academic or industrial setting); Recent/current experiencegreatlypreferred
Experience of cancer genomics and analysis ofoncologyclinical specimens
Strongcurrentlaboratory and analytical skills
Evidence of effective problem-solving methoddevelopmentand optimisation
Ability to understand and work to detailed SOPsand to authorand troubleshootnew SOPs
Excellentoral and written communication skills able to document work clearly concisely and understand and describe its importance to others
Good organisational and planning skills ability to manage a portfolio of work prioritizeand deliver to agreed time and quality
Good interpersonal skills able to work effectively with colleagues/collaborators from diverse backgrounds levels of seniorityand territories
Meticulous attention to detail ability to document results to a high standard
Desirable skills and experience:
Although training will be given where experience in the following areas would be a distinct advantage:
Peer-reviewed publications in thecancer biology/cancergenomicsfield
Working in a commercial/industrial environment
Working withDNA/RNA fromhuman clinical materials such as formalin fixed paraffin-embedded tissues frozen tissues plasma(circulatingcell-free DNA/cfDNA).
Hands-on laboratory experience preparingDNA/RNAlibraries targeted NGSand running NGSplatforms
Work in single cellgenomics and/or spatial genomics (e.g.10x ParseGeoMxDSP)
Tissue culture handling and purification of cells from clinical samples e.g. PBMCs
Tissue dissociation for downstream single cell work
Developing and running assays(e.g.mutation/copy number)using digital PCR
Conductingworkto Good Clinical Practice (GCP)within aregulatory/qualityframework (e.g. ISO15189- CAP- CLIA-accredited lab environment).
Assaydevelopment for NGS platforms
Working with laboratory automation(particularlyBiomekliquid handling systems) method development/optimisation
Analysis and interpretationof NGS datafrom clinical specimens
Experience in the biotech/pharmaceutical industry and of the drug development process
When we put unexpected teams in the same room we unleash ambitious thinking with the power to encourage lifechanging medicines. Inperson working helps us connect work at pace and challenge perceptions. We work on average a minimum of three days per week from the office while balancing individual flexibility.
Why AstraZeneca
We are committed to making a difference and have built our business around our passion for science. Were fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. Our curiosity and courage drive us to do things that havent been done beforeempowered to step up make bold decisions and learn from successes and failures.
Ready to make a significant impact Apply now and join us on this exciting journey!
Date Posted
23-Jan-2026Closing Date
05-Feb-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Required Experience:
Senior IC
Key Skills
- Laboratory Experience
- Mammalian Cell Culture
- Biochemistry
- Assays
- Protein Purification
- Research Experience
- Next Generation Sequencing
- Research & Development
- cGMP
- Cell Culture
- Molecular Biology
- Flow Cytometry
About Company
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, ... View more
