Senior Research Scientist, Human Cell Engineering and In Vitro Disease Modeling
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Job Location:
San Diego, CA - USA
Monthly Salary:
$ 121600 - 182400
Posted on:
13 hours ago
Vacancies:
1 Vacancy
Job Summary
Job Description
Vertex Pharmaceuticals isseekinga highly skilled and motivatedSenior Research Scientistto join our Disease Modeling this role you willbe responsible forthe development of engineered human cellmodelsand their integration into drug discovery workflows supporting translational relevance and enabling the advancement of Vertexs will applyexpertisein human cell biology primary cell systems iPSC technologies and gene editing to develop robust in vitro disease models that support target validation proof-of-concept studies primary screening selectivity and efficacy assessmentsmechanism of actionstudies andmedicinal chemistry ideal candidate brings strong technical depth scientific curiosity and the ability to work effectively across multidisciplinary teams. This is a full time onsite position in San Diego.
Key Responsibilities
- Design generate QC andvalidateengineered human cell lines; perform functional characterization of genetic edits and prepare documentation for internal review.
- Establish andmaintainquality control criteria fordifferentcell types and disease model systems.
- Contribute to the design and development of human in vitro disease models that recapitulate disease mechanisms and phenotypes.
- Perform andoptimizeprimary cell culture iPSC differentiationtransdifferentiation and gene-editing workflows.
- Collaborate with cross-functional project teams to integrate disease models into compound screening target validation and mechanistic studies.
- Analyze datasets preparehigh-qualityexperimental summaries and communicate findings to project teams and functional leadership.
- Maintain awareness of emerging technologies in gene editing cell engineering and in vitro disease modeling.
- Contribute to continuous improvement of methodologies tools and best practices within the group.
Knowledge and Skills:
- Strong ability to analyze complex datasets review scientific literature and formulate hypotheses.
- Demonstratedexpertisewith humancell basedsystems for disease modeling and therapeutic development.
- Extensive hands-on experienceestablishingiPSC differentiation workflows across multiple cell lineages.
- Proficiencywith CRISPR/Cas9 gene editing and its application in disease modeling.
- Hands-on competence with standard validation methods (RNAseq qPCR/ddPCR NGS Western blot immunostaining).
- Strong organizational communication and interpersonal skills.
- Ability to manage multiple high-impact projects in afast pacedenvironment with excellent prioritization and execution.
- Demonstrated ability to work both independently and collaboratively within a matrixed organization.
- Strong publication record and evidence of contributions to drug discovery programs.
Required Qualifications
- Ph.D. in Cell Biology Molecular Biology Neuroscience orrelateddiscipline and 2-5 years of relevant post-doctoral employment experience or
- Masters Degree (or equivalent degree) in molecular biology cell biology biochemistry or related disciplines and 5 years of relevant employment experience or
- Bachelors Degree (or equivalent degree) in molecular biology cell biology biochemistry or related disciplines and 8 years of relevant employment experience
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Pay Range:
$121600 - $182400Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors including skills competencies experience and other job-related factors permitted by law.
At Vertex our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career financial family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter) educational assistance programs including student loan repayment a generous commuting subsidy matching charitable donations 401(k) and so much more.
Flex Designation:
On-Site DesignatedFlex Eligibility Status:
In this On-Site designated role you will work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.
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Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race color sex gender identity or expression age religion national origin ancestry ethnicity disability veteran status genetic information sexual orientation marital status or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager or contact Talent Acquisition at
Required Experience:
Senior IC
Key Skills
- Laboratory Experience
- Machine Learning
- AI
- Bioinformatics
- Biochemistry
- Assays
- Research Experience
- Next Generation Sequencing
- Drug Discovery
- Research & Development
- Natural Language Processing
- Molecular Biology
About Company
Vertex Pharmaceuticals invests in scientific innovation to create transformative medicines for people with serious diseases.
