Senior Director, Portfolio Management

Please note that this position can be based in either Princeton NJ San Diego CA or South San Francisco CA. Acadias hybrid model requires this role to work in our office an average of 3 days per week.

Position Summary

The Senior Director of Portfolio Management will play a pivotal role in shaping and executing the strategic direction of the companys development and commercialization portfolio. Operating within a dynamic matrixed environment this leader will drive enterprise-wide portfolio prioritization facilitate cross-functional alignment and enable efficient decision-making to maximize value creation. This role requires deep collaboration with key stakeholders across Finance R&D and Commercial to ensure that portfolio investments are strategically sound financially viable and aligned with market opportunities and scientific innovation.

Primary Responsibilities

• Lead the development and implementation of portfolio prioritization frameworks that balance scientific innovation commercial potential and financial impact.
• Partner closely with Finance to assess investment scenarios optimize resource allocation and ensure portfolio decisions are grounded in financial rigor.
• Collaborate with R&D leadership to align pipeline strategy with portfolio goals ensuring scientific feasibility and milestone-driven execution.
• Engage with Commercial teams to incorporate market insights competitive intelligence and launch readiness into portfolio planning.
• Facilitate governance processes that promote transparency agility and accountability across the portfolio lifecycle.
• Drive continuous improvement in portfolio operations leveraging data and analytics to inform strategic decisions and enhance execution efficiency.
• Lead focused initiatives supporting continuous improvement of Acadias Portfolio Governance and Operating Model.
• Serve as a trusted advisor to Portfolio Governance (PG) providing clear actionable insights on portfolio performance trade-offs and strategic risks.
• Champion a culture of accountability collaboration and innovation across teams and functions.
• Other responsibilities as assigned.

Education/Experience/Skills

• Bachelors degree in life science or related field; Advanced degree preferred. Targeting 12 years of progressively responsible relevant experience focusing on program management with 8 years in a leadership role which includes experience managing cross-functional project teams. A successfulcandidate will have a strong understanding of the drug development process from preclinical pharmacology through to regulatory approval and the principles concepts practices and standards of pharmaceutical program management. An equivalent combination of relevant education and experience may be considered.

Key Skills:

• Significant amount of experience required in portfolio management strategic planning or program leadership within the biotech or life sciences industry.
• Proven ability to lead cross-functional teams and influence senior stakeholders in a matrixed environment.
• Strong understanding of drug development processes commercialization strategies and financial modeling.
• Executive presence and exceptional communication analytical and problem-solving skills.
• Experience with governance frameworks and enterprise operating models is highly desirable.
• Advanced meeting facilitation skills and ability to lead cross-functional teams that include executive and senior management without direct authority.
• Ability to elicit cooperation from a wide variety of sources and to be persuasive encouraging and motivating.
• In-depth knowledge and skill with Microsoft (MS) suite including MS PowerPoint MS Project MS Word MS Excel.
• Must be able and willing to travel on occasion.

Physical Requirements

This role involves regular standing walking sitting and the use of hands for handling or operating equipment. The employee may also need to reach climb balance stoop kneel crouch and maintain visual verbal and auditory communication in a standard office environment and while working independently from remote locations. The employee must occasionally lift and/or move up to 20 pounds. This position requires the ability to travel independently overnight and/or work after hours as required by travel schedules or business needs.

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Required Experience:

Exec