Senior Principal Scientist Biotransformation
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Job Summary
Job Description
General Summary:
Vertex is seeking a highly motivated and experienced Senior Principal Biotransformation Scientist to join our Oxford team. The successful candidate will play a leading role in the delivery of biotransformation and metabolite characterization support to our drug discovery and development projects.
The successful candidate will have a deep analytical background in high resolution mass spectrometry and metabolite identification with an established track record for designing executing and interpreting bespoke biotransformation studies. They will be responsible for the delivery of critical in vitro and in vivo biotransformation knowledge to aid medicinal chemistry design and influence key decisions impacting drug discovery and clinical development.
Key Duties and Responsibilities:
- Provide mass spectrometry and metabolite identification expertise to the DMPK organization keeping abreast of new scientific developments related to biotransformation science
- Proactively apply deep biotransformation scientific expertise to design and deliver metabolism studies in line with DMPK and project key deliverables
- Understand interpret and communicate biotransformation data to Project Representatives and key stakeholders to aid medicinal chemistry design and influence key decisions
- Be able to troubleshoot problem-solve and define best practice for biotransformation studies
- Drive innovation by investigating and implementing new analytical technologies and procedures
- Contribute to the wider global biotransformation strategy to grow biotransformation science at Vertex
- Create internal and external networks to drive science within their discipline
- Author study reports
- Ensure high levels of data integrity and data accessibility
- Provide training and mentoring to more junior biotransformation colleagues
Knowledge and Skills:
- Proven ability of metabolite characterisation and quantification using high resolution mass spectrometry and state-of-the-art metabolite acquisition and processing software
- Deep knowledge of biotransformations with extensive proven experience applying this to drug discovery and development programs
- Good understanding of in vitro and in vivo approaches used to understand biotransformation issues
- Ability to work in a matrix environment and problem solve with an extensive track record of generating high quality data and reports
- Excellent communication interpersonal and team working skills
- Track record of developing more junior biotransformation scientists
Education and Experience:
- BSc or equivalent in relevant field (PhD desirable) or equivalent relevant working experience.
Flex Designation:
On-Site DesignatedFlex Eligibility Status:
In this On-Site designated role you will work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.
#LI-Onsite
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race color sex gender identity or expression age religion national origin ancestry ethnicity disability veteran status genetic information sexual orientation marital status or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager or contact Talent Acquisition at
Required Experience:
Staff IC
Key Skills
- Machine Learning
- Python
- Data Science
- AI
- R
- Research Experience
- Sensors
- Drug Discovery
- Research & Development
- Natural Language Processing
- Data Analysis Skills
- Toxicology Experience
About Company
Vertex Pharmaceuticals invests in scientific innovation to create transformative medicines for people with serious diseases.
