Associate Principal Scientist, In Vitro Quantitative Biosciences

Job Description

We are seeking an experienced and innovative Associate Principal Scientist with a strong background in supporting in vitro pharmacology for early drug discovery to join the External Quantitative Biosciences group (ExQB).

Under the broad direction of a Principal Scientist in ExQB the candidate will support the execution of externalized In vitro biology projects across all discovery sites in our Research and Development divisions disease areas as well as participate in relationship management of Contract Research Organizations (CRO). The ideal candidate will be an experienced in vitro biology bench scientist and team player with experience supporting collaborations across a broad range of discovery biology collaboration with Quantitative Biosciences (QB) this individual will effectively assess and grow our external early discovery in vitro biology capabilities to drive pipeline support in line with our companys broader externalization strategies. Strong communication leadership and problem-solving skills as well as ability to network apply soft skills operate in the grey space and apply excellent interpersonal skills are crucial to success in this role.

Key responsibilities include but are not limited to the following:

• Relying on in vitro biology lab bench experience partner with pharmacologists from QB and scientists from other discovery functions to define and challenge resource demands and support the continued build of strategies workflows and capability builds at strategic CRO partners to support screening and external reagent generation in a rapidly changing environment.

• Provide tactical and scientific support to transfer in vitro pharmacology/biology screening funnels assays technology and processes in alignment with the unified screening strategy shared between ExQB External Discovery Chemistry and DMPK outsourcing teams to maintain and improve Design Make Test Analyze (DMTA) cycle time.

• Plan and participate in partner site visits to evaluate in vitro biology workflows practices capabilities safety procedures and compliance standards as well as build and optimize workflows to complement internal company processes including working with our companys IT to enable data transfer.

• Oversee partner scientific workflows and together with Discovery Operations team and procurement manage the business relationship between our company and CROs through various governance meetings processes and performance feedback.

• Work closely with Procurement and Business Development & Licensing teams to support business sourcing management and licensing needs by scientifically representing in vitro biology sourcing needs.

• Routinely gather categorize and translate external resource demand across in vitro biology disciplines and share with Finance and Discovery Operations to manage and update spend forecasts

Required Experience and Skills:

• While this is not a lab-based position this role requires substantial bench-level experience and expertise in in vitro biology/pharmacology. As such a minimum of a Bachelors Degree (BA/BS) in Biology In Vitro Pharmacology Pharmaceutical Science Molecular Biology Biochemistry Biophysics or a related STEM discipline with 8 years of relevant industry lab experience a Masters Degree (MA/MBA/MS) with 6 years of relevant industry lab experience or a PhD with 4 years of relevant industry lab experience is required.

• Lab-based expertise in applying plate-based In Vitro pharmacology principles and best practices across multiple disease areas with experience in designing interpreting and troubleshooting studies as well as significant experience in performing automated plate-based assays for DMTA/SAR support in a time-critical fashion is needed.

• Working understanding of global pharmaceutical and CRO industries with a solid understanding of drug discovery as well understanding pharmacologys role within drug discovery.

Preferred Experience and Skills:

• Expertise in biochemistry/protein biochemistry biophysics and/or molecular biology is strongly preferred

• Strong understanding of in vitro pharmacology business standards including data QC protocol design laboratory processes and best-practices as well as safety standards.

• Expertise in cell pharmacology lab automation and/or discovery biomarker research including -omics

• A minimum of 3 years in managing CRO relationships or equivalent relationship management role.

• Established network within our company as well as Strategic CROs and biotech / large pharma.

• Successful track record of working with multiple functional groups or teams across cultural and geographic boundaries.

The location can be at any of our companys East Coast Research Laboratory locations (Research and Development Division) including Boston MA Cambridge MA Rahway NJ or West Point PA sites.

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The salary range for this role is

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including but not limited to relevant education qualifications certifications experience skills geographic location government requirements and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive if applicable.

We offer a comprehensive package of benefits. Available benefits include medical dental vision healthcare and other insurance benefits (for employee and family) retirement benefits including 401(k) paid holidays vacation and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

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