Principal Scientist, Protein Engineering

Job Description

Our company is a global health care leader with a diversified portfolio of prescription medicines vaccines and animal health products. Our teams combine leading drug discovery capabilities and world-class R&D with the purpose of turning breakthrough science into life-changing medicines.

Our Research and Development Division in San Diego is a cross-functional team (Discovery Biologics Immunology and Data Science) with the goal to discover and develop novel innovative therapeutics in the field of Inflammation and Immunology. The Discovery Biologics Department is seeking an exceptional and experienced scientist candidate to drive biologics discovery and development. The role is a key interface with Immunology and other drug discovery and development scientists and functions across our company as well as with external academic and industrial partners. The successful candidate will lead projects from discovery to start of IND-enabling studies with focus on antibodies bispecific molecules and evaluation of novel biologic platforms and mechanisms of action.

We recognize that diversity of thought and experiences in our team are our strengths and we are committed to creating an inclusive environment for all employees. Successful candidates must demonstrate inclusive behaviors in collaboration with colleagues to drive our core mission.

Key Responsibilities:

• Lead the design engineering and characterization of innovative biologics including antibodies and bispecific molecules.

• Direct the Protein Sciences team in the production and purification of antibodies in mammalian cell lines including transient HEK CHO; and antigen and protein reagents required for the drug discovery portfolio.

• Drive innovation by contributing to exploratory programs and technology development.

• Strategic project leadership in Immunology Biologics partnering cross-functionally with teams in discovery pharmacokinetics pharmacodynamics toxicology CMC translational sciences and translational medicine.

• Lead and mentor a team of scientists.

• Foster a high-performance culture of collaboration engagement self-accountability and inclusion.

• Effectively partner across multidisciplinary interfaces to achieve organizational objectives.

• Stay abreast of external advancements in the relevant scientific fields.

• Promote the external reputation of the Discovery Biologics Department by contributing to publications and conference presentations.

Qualifications:

Education:

• Bachelors (with 14 years) Masters (with 10 years) or Ph.D. (with 7 years) in Immunology Molecular Biology Biochemistry Cellular Biology or related field and relevant experience.

Required Experience and Skills:

• Deep scientific knowledge across workflows and domains integral to the discovery and development of protein therapeutics.

• Expertise in therapeutic protein design engineering and characterization.

• Experience advancing a biotherapeutic programs from Discovery into Development and driving the application of scientific or platform innovations.

• Demonstrated passion for and a track record of talent development.

• Champion for a diverse and inclusive culture.

• Excellent verbal and written communication skills.

• Strong external reputation through publications presentations and scientific community engagement.

Preferred Experience and Skills:

• Experienced in protein therapeutics beyond traditional mAbs including alternative non-Ig scaffolds bi- or multispecifics and fusion proteins.

• Fluency with techniques for analysis of protein-protein interactions.

• Knowledge of computational approaches for protein engineering.

• Experience in outsourcing and managing external collaborations.

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Required Skills:

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Our company is committed to inclusion ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race color age religion sex sexual orientation gender identity national origin protected veteran status disability status or other applicable legally protected a federal contractor we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws visit:

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We are proud to be a company that embraces the value of bringing together talented and committed people with diverse experiences perspectives skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas broad experiences backgrounds and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one anothers thinking and approach problems collectively.

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U.S. Hybrid Work Model

Effective September 5 2023 employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week Monday - Thursday although the specific days may vary by site or organization with Friday designated as a remote-working day unless business critical tasks require an on-site Hybrid work model does not apply to and daily in-person attendance is required for field-based positions; facility-based manufacturing-based or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note this Hybrid work model guidance also does not apply to roles that have been designated as remote.

The salary range for this role is

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including but not limited to relevant education qualifications certifications experience skills geographic location government requirements and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive if applicable.

We offer a comprehensive package of benefits. Available benefits include medical dental vision healthcare and other insurance benefits (for employee and family) retirement benefits including 401(k) paid holidays vacation and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:We will consider for employment all qualified applicants including those with criminal histories in a manner consistent with the requirements of applicable state and local laws including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance

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Merck & Co. Inc. Rahway NJ USA also known as Merck Sharp & Dohme LLC Rahway NJ USA does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place introductions are position specific. Please no phone calls or emails.

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