Principal Research Scientist I, Lipid Design and Formulations Development
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Job Location:
San Diego, CA - USA
Monthly Salary:
Not Disclosed
Posted on:
2 days ago
Vacancies:
1 Vacancy
Job Summary
Overview
We are seeking a highly motivated and innovative Formulation Scientist to join our LNP development this role you will be responsible for leading projects focused on lipid design formulation development and characterization of targeted LNP drug products to support internal platform and pipeline programs. The ideal candidate will have a deep understanding of LNP formulation and lipid chemistry analytical characterization and functional screening in vitro and in vivo.
Responsibilities
- Independently lead research efforts through deep technical understanding and work collaboratively within a cross-functional product development team to drive design functional screening development and production of novel tLNP formulations for targeted extra hepatic delivery of nucleic acid payloads.
- Discover and optimize novel lipid designs and applications from diverse structural families for LNP platform technology development
- Collaborate with various groups across the organization including mRNA analytical conjugation antibody and CMC process development groups to advance pipeline programs
- Routinely act as a group leader on formulation projects and provide mentorship to a small group of research associates.
- Contribute to formulations/process development sections of regulatory filings (IND NDA etc.)
- Review scientific literature patents scientific abstracts to stay up to date on latest in the field. Provide scientific expertise in the organization with special emphasis on lipid nanoparticle-based drug targeting delivery systems for nucleic acids
Qualifications :
- BS or equivalent education and extensive typically 14 years of industry experience; MS or equivalent education with typically 12 years of industry experience; PhD with typically 6 years of industry experience in scientific area of discipline.
- Preferred: PhD in Chemistry Biochemistry Bioengineering or Pharmaceutical Sciences with experience in the design and development of nanoparticle-based drug delivery systems or complex biologics.
- Deep technical prowess is required with respect to lipid chemistry and LNP formulation. Demonstrated ability to establish new capabilities and innovate strategies in pursuit of scientific excellence.
- Must possess in depth understanding of all aspects of formulation development as well as downstream characterization including physicochemical stability and biological evaluation.
- Experience with process: lipid nanoparticle formulation and purification processes and/or experience with process development scale-up/out engineering and GMP manufacturing of biologic drug product processes are highly desired.
- Experience with supervision mentorship or training of other team members.
- Good track record of scientific publications and patents in the field of lipid nanoparticle-based drug delivery systems is desired
- Must be an independent thinker with a passion for developing novel formulation technologies.
- Experience in contributing to formulation and pharmaceutical development sections of regulatory filings is highly desirable.
- Details oriented with good organization skills great troubleshooting skills team player excellent oral and written communication skills are necessary for this position.
Additional Information :
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
- The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at thetime of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic locationand we may ultimately pay more or less than the posted range. This range may be modified in the future.
- We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.
- This job is eligible to participate in our short-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of anybonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys soleand absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more visit & Puerto Rico applicants seeking a reasonable accommodation click here to learn more:
No
Employment Type :
Full-time
Key Skills
- Machine Learning
- Python
- Data Science
- AI
- R
- Research Experience
- Sensors
- Drug Discovery
- Research & Development
- Natural Language Processing
- Data Analysis Skills
- Toxicology Experience
About Company
AbbVie is a global biopharmaceutical company focused on creating medicines and solutions that put impact first for patients, communities, and our world. We aim to address complex health issues and enhance people's lives through our core therapeutic areas: immunology, oncology, neuro ... View more
