Senior Research Associate, Platform Technology
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Job Location:
Cambridge, MA - USA
Monthly Salary:
Not Disclosed
Posted on:
15 hours ago
Vacancies:
1 Vacancy
Job Summary
About Us
Deep Genomics is at the forefront of integrating artificial intelligence and complex biology to transform drug discovery. Our proprietary machine learning platform decodes the complexity of RNA biology to identify novel drug targets mechanisms and therapeutics inaccessible through traditional methods. With expertise spanning machine learning bioinformatics data science genetics chemistry and drug development our multidisciplinary team in Toronto and Cambridge MA is revolutionizing how medicines are created.
About the Role
We are seeking a highly motivated Senior Research Associate to join our Platform Technology team and play a critical role in advancing our AI-enabled RNA therapeutics discovery this position you will design implement and optimize genomics-based assays that power therapeutic discovery screening and validation across a wide range of cellular systems. You will support high-throughput evaluation of novel RNA therapeuticsincluding modalities such as ADAR editing ASOs siRNAs and mRNAsand generate high-quality molecular data that directly feeds into computational models and therapeutic decision-making.
As a key contributor within a dynamic research environment you will collaborate closely with computational scientists platform biologists and therapeutic program teams. You will develop and execute next-generation sequencing assays functional genomics readouts and high-throughput molecular screens that drive target validation lead optimization and drug profiling.
This role is ideal for candidates who thrive in a fast-paced cross-functional setting and enjoy building and scaling cutting-edge experimental technologies.
Key Responsibilities
- Design execute and optimize high-throughput genomics assays including NGS workflows targeted sequencing RNA-seq and high-content gene expression readouts to evaluate RNA therapeutic candidates.
- Sequence prepared libraries independently using instruments such as the Illumina NextSeq including run setup instrument operation and routine troubleshooting.
- Troubleshoot library prep QC metrics and workflow bottlenecks to ensure consistently high-quality datasets for computational analysis.
- Implement automated workflows using liquid handlers (e.g. Hamilton STAR Agilent Bravo Beckman Echo) to scale discovery and screening activities.
- Perform a broad range of molecular biology techniques including PCR qPCR/ddPCR and nucleic acid extractions on a variety of cell types and tissues.
- Clearly document experimental plans results SOPs troubleshooting steps and data within an electronic lab notebook (ELN).
- Present experimental findings and assay performance updates to project teams and collaborators.
Basic Qualifications
- BS or MS in Molecular Biology Genetics Genomics Biotechnology Biochemistry or related discipline with 36 years of relevant industry experience.
- Strong understanding of molecular and cell biology principles.
- Experience with NGS library preparation including amplicon-seq bulk RNA-seq targeted panels or single-cell sequencing.
- Experience extracting RNA/DNA from cells and animal tissues.
- Demonstrated proficiency in designing and executing genomics-based or molecular assays.
- Excellent communication organizational and documentation skills.
- Ability to prioritize and drive work independently in a fast-paced research environment.
Preferred Qualifications
- Proficiency with specific liquid handling platforms such as Hamilton STAR Agilent Bravo or Beckman Echo.
- Familiarity with RNA therapeutic modalities (ADAR editing ASOs siRNAs mRNA).
- Hands-on experience growing maintaining and transfecting mammalian cells.
- Prior experience in a biotechnology pharmaceutical or platform-driven discovery environment and demonstrated ability to collaborate within a highly cross-functional and multidisciplinary team.
What we offer
- A collaborative and innovative environment at the frontier of computational biology machine learning and drug discovery.
- Highly competitive compensation including meaningful stock ownership.
- Comprehensive benefits - including health vision and dental coverage for employees and families employee and family assistance program.
- Flexible work environment - including flexible hours extended long weekends holiday shutdown unlimited personal days.
- Maternity and parental leave top-up coverage as well as new parent paid time off.
- Focus on learning and growth for all employees - learning and development budget & lunch and learns.
- Facilities located in the heart of Toronto - the epicenter of machine learning and AI research and development and in Kendall Square Cambridge Mass. - a global center of biotechnology and life sciences.
Deep Genomics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.
Deep Genomics thanks all applicants however only those selected for an interview will be contacted.
We may use artificial intelligence (AI) tools to support parts of the hiring process such as reviewing applications analyzing resumes or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed please contact us.
Required Experience:
Senior IC
Key Skills
- Laboratory Experience
- Immunoassays
- Mammalian Cell Culture
- PCR
- Biochemistry
- Assays
- Cell Biology
- Research Experience
- Cell Culture
- Molecular Biology
- Flow Cytometry
- Western Blot
About Company
Revolutions in AI, biology and automation are enabling a new approach to medicine. Deep Genomics is at the forefront.
