Senior Scientist – In Vivo Mouse Genome Engineering
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Monthly Salary:
Posted on:
6 hours ago
Vacancies:
1 Vacancy
Job Summary
Are you an in vivo biologist who thrives at the bench and wants to turn cutting-edge genome engineering into transformative therapies for rare diseases Do you want to collaborate across disciplines to translate innovative editing technologies into robust decision-driving in vivo data. Join us to design deliver and optimize nextgeneration editors directly in mice to advance curative gene therapies.
We have a great opening for a Senior Scientist with demonstrated expertise in in vivo mouse studies and genome engineering. You will join the Genome Engineering In Vivo Models team within Discovery Sciences and focuse on in vivo genome modification in mouse models. The role is located at our vibrant R&D site in Gothenburg Sweden.
What youll do
This is a laboratory-based role where you will plan and conduct end to end mouse studies including dosing tissue collection necropsy and sample processing in accordance with ethical and regulatory standards. You will also prepare and administer CRISPR/Cas9 base and prime editors guide RNAs and donor templates via appropriate routes (e.g. IV IP IT IM) and modalities (e.g. AAV LNP viral and non viral systems).
Typical accountabilities will include:
Data generation and analysis: Quantify on target editing and functional outcomes using NGS (targeted amplicon or capture) qPCR/dPCR and protein/biomarker assays; contribute to off target risk assessment
Study design and optimization: Optimize dose route schedule tissue targeting and delivery vehicle selection across relevant strains and disease models to meet program objectives
Documentation and reporting: Maintain accurate records ensure data integrity and traceability and deliver clear study reports and presentations to drive project decisions
Cross-functional collaboration: Partner with genome engineering pathology and bioinformatics teams to troubleshoot interpret data and advance milestones
Essential requirements for the role:
Ph.D. or equivalent industrial/academic experience in a relevant discipline (e.g. in vivo pharmacology molecular biology genetics biomedical engineering)
Hands on expertise with in vivo mouse procedures
Practical experience with genome editing technologies; experience translating in vitro to in vivo preferred
Proficiency in analysis of genome editing outcomes from in vivo samples (NGS qPCR/dPCR protein/biomarker quantification)
Strong organizational documentation and data management skills; proficiency with electronic lab notebooks and sample tracking
Effective communication skills and a collaborative working style with a delivery focus
Compliance with institutional animal care and welfare standards is required; relevant certifications are preferred
Why AstraZeneca
At AstraZeneca we are united by a common purpose: to push the boundaries of science to deliver life changing medicines. You will join an inclusive science led organization with the resources and cross functional expertise to translate innovative genome engineering into therapeutic impact.
Whats next
If this sounds like the place and job for you welcome to apply today! We look forward to get to know you better. Send in your application no later than January 16 2026. For more information about the position please contact hiring manager Michelle Porritt at
Please note: Due to the holiday season our response to your application may take longer than usual. Thank you for your patiencewe will follow up when we return in January.
Date Posted
19-dec.-2025Closing Date
16-jan.-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Required Experience:
Senior IC
Key Skills
- Laboratory Experience
- Mammalian Cell Culture
- Biochemistry
- Assays
- Protein Purification
- Research Experience
- Next Generation Sequencing
- Research & Development
- cGMP
- Cell Culture
- Molecular Biology
- Flow Cytometry
About Company
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, ... View more
