This is what you will do:
The Senior Manager US Health Economics and Outcomes Research is a mid-entry level role on the US HEOR Real World Evidence (RWE) Team based out of our Boston Headquarters. The Senior Manager US HEOR RWE assists with the submission and assumes project owner status of US HEOR material within the internal Medical Legal and Regulatory Review process (MMR). This individual also works closely with the RWE Therapeutic Area TA Leads providing project updates across each TA within RWE tracking platforms and US Medical Affairs Leadership Teams quarterly business review. The Senior Manager US HEOR will function as a study co-lead within an assigned therapeutic area under the supervision of the US HEOR RWE TA lead. This individual will also perform statistical analyses using in-house datasets to provide rapid response to RWE queries.
You will be responsible for:
Works closely with and under the guidance of US HEOR Executive Director US RWE study leads and US HEOR field team to develop field-facing materials that help maximize formulary positioning of Alexion in-line brands.
Partners with US and Global HEOR TA Leads to assist in the development of strategies and research plans that offer robust differentiated payer evidence.
Acts as the liaison between US HEOR and US Medical Review / MMR across all therapeutic areas in Alexions portfolio.
Assists with the timely execution and review of US HEOR Medical and Promotional Materials.
Continually gathers insights from field colleagues to uncover market access issues and trends
Works closely with US RWE study leads in an assigned TA with planning budgeting executing strategic positioning and communication of evidence generation studies.
Assumes primary vendor management role on assigned projects within a specific TA or Above Brand strategies.
Conducts literature review and healthcare data analysis using platform-based tools and Excel.
Identifies areas for process improvements economies of scale and other quality and efficiency measures.
You will need to have:
Bachelors Degree in health science related field (life sciences public health health economics or related field etc.). Masters degree is preferred.
Proficient knowledge of observational study design and methodology and the applicability of insurance claims datasets for evidence generation.
General understanding of the US healthcare landscape and drug reimbursement (commercial insurance Medicare and Medicaid)
Ability to work in a matrixed environment and solve complex issues that cross multiple stakeholders
Excellent interpersonal skills with a track record of effectiveness as a team player; excellent oral/written communication and presentation skills
Excellent project leader who can effectively manage multiple competing priorities to completion.
Global mindset and ability to work with multicultural teams.
Flexibility and adaptability to internal and external change.
We would prefer for you to have:
Experience and knowledge in rare disease conditions
The annual base salary for this position ranges from $113000 to $170000. However base pay offered may vary depending on multiple individualized factors including market location job-related knowledge skills and addition our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles) or to receive a retirement contribution (hourly roles). Benefits offered included a qualified retirement program 401(k) plan; paid vacation and holidays; paid leaves; and health benefits including medical prescription drug dental and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired employee will be in an at-will position and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time including for reasons related to individual performance Company or individual department/team performance and market factors.
Date Posted
16-Dec-2025Closing Date
05-Feb-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and furtherance of that mission we welcome and consider applications from all qualified candidates regardless of their protected characteristics. If you have a disability or special need that requires accommodation please complete the corresponding section in the application form.
Required Experience:
Senior Manager
Alexion is a global biopharmaceutical company focused on developing life-changing therapies for people living with rare disorders.